11684434
Beschreibung
Quiz von Melanie Grynsztejn, aktualisiert more than 1 year ago
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Erstellt von Melanie Grynsztejn
vor mehr als 6 Jahre
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Frage 1
Frage
Pharmacogenetics is study of inherited genetics [blank_start]difference[blank_end] in drug [blank_start]metabolic[blank_end] pathways which can affect [blank_start]individual[blank_end] responses to drugs, both in terms of therapeutic effect as well as adverse effects
Antworten
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difference
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sameness
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metabolic
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pharmacokinectic
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individual
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ethnic group's
Frage 2
Frage
Nearly [blank_start]90%[blank_end] of general population have CYP2D6 functional duplication allele
o [blank_start]10%[blank_end] has inactive copies of CYP2D6 = codeine has no analgesic effect
o [blank_start]2-5%[blank_end] ultrarapid metabolizer
Antworten
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90%
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80%
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70%
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10%
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20%
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5%
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2-5%
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5-10%
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10-15%
Frage 3
Frage
Codeine is metabolized by an enzyme that is genetically regulated called CYP2D6 in the liver that turns codeine into morphine
Antworten
- True
- False
Frage 4
Frage
CYP2D6 is responsible for the metabolism of which drugs
Antworten
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Analgesics
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BB
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CCB
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Antidepressants
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Antispsychotics
Frage 5
Frage
The CYP2C19 metabolizes which drugs
Antworten
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Plavix (clopidogrel)
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Coumadin (warfarin)
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Dabigatran (Pradaxa)
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Apixaban (Eliquis)
Frage 6
Frage
GeneSight Tests for
Antworten
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ADHD
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Analgesic
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MTHFR
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Psychotropic
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Anticoagulants
Frage 7
Frage
Genotype is
Antworten
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genetic constitution, alleles present at one locus
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manifestation of genes
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phenotypic differences
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proportion of heterozygous population expressing the phenotype
Frage 8
Frage
Phenotype is:
Antworten
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genetic constitution, alleles present at one locus
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manifestation of genotype
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phenotypic differences in same genotype
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proportion of heterozygous population expressing the phenotype
Frage 9
Frage
Variable expressivity is
Antworten
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genetic constitution, alleles present at one locus
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manifestation of genotype
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phenotypic differences in same genotype
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proportion of heterozygous population expressing the phenotype
Frage 10
Frage
Penetrance is
Antworten
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genetic constitution, alleles present at one locus
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manifestation of genotype
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phenotypic differences in same genotype
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proportion of heterozygous population expressing the phenotype
Frage 11
Frage
Autosomal dominant inheritance
Antworten
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Required one copy of gene mutation to express the associated condition
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Phenotype is expressed in person heterozygous for a particular allele
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Requires two copies of gene mutation (one from each parent) to manifest the condition
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Phenotypes is expressed in person homozygous for a particular allele
Frage 12
Frage
Autosomal recessive:
Antworten
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Requires one copy of gene mutation to express the associated condition
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Phenotype is expressed in person heterozygous for a particular allele
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Requires two copies of gene mutation (one from each parent) to manifest the condition
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Phenotypes is expressed in person homozygous for a particular allele
Frage 13
Frage
Breast cancer is [blank_start]5 - 10%[blank_end] hereditary
Antworten
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5 - 10%
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0 - 5%
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10 - 15%
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15 - 20 %
Frage 14
Frage
Which a mutation in which BRCA gene has a 40% lifetime risk for ovarian cancer
Antworten
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BRCA-1
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BRCA - 2
Frage 15
Frage
Tamoxifen is metabolized by
Antworten
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CYP2D6
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CYP2CI9
Frage 16
Frage
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers including endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin
Antworten
- True
- False
Frage 17
Frage
Amsterdam II criteria for HNPCC/Lynch Syndrome includes 3 relatives with CRC (colorectal cancer) and other HNPCC cancer in the family. Select the HNPCC cancers:
Antworten
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Hepatic
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Colon
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Endometrium
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Small bowen
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Pancreatic
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Renal pelvis
Frage 18
Frage
Pharmacogenetics is the study of _________
Antworten
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germline mutations
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x-linked mutations
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autosomal dominant mutations
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autosomal recessive mutations
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