412616
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
What is the role of the Rb Susceptibility gene?
Antworten
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Nuclear transcription factor
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Nuclear phosphatases
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Nuclear phosphorylases
Frage 2
Frage
What protein does Rb bind to?
Antworten
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E2F
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FF2
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EF2
Frage 3
Frage
What is the role of the protein bound to Rb?
Antworten
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Transcription factor
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Kinase
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Phosphatase
Frage 4
Frage
What are the target genes of the Rb bound protein?
Antworten
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dNTP producing genes
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Transcription factor producing genes
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Growth factor producing genes
Frage 5
Frage
How is Rb phosphorylated and deactivated?
Antworten
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By Cyclin
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By CDK
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By a cyclin/CDK dimer
Frage 6
Frage
What protein phosphorylates CDK?
Antworten
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CAK
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CAD
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CAB
Frage 7
Frage
Which forms first during G1?
Antworten
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CDK/Cyclin D
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CDK/Cyclin E
Frage 8
Frage
What causes the production of Cyclin/CDK E &D?
Antworten
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Jun Activity
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AP1 Activity
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Myc Activity
Frage 9
Frage
Which is required to activate E2F?
Antworten
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Cyclin/CDK D
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Cyclin/CDK E
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Both
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Neither
Frage 10
Frage
Name 3 CDK inhibitors
Antworten
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p13
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p21
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p12
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p16
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p27
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p19
Frage 11
Frage
Which of the following binds to CDK, & twists its head to block the active site?
Antworten
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p16
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p12
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p19
Frage 12
Frage
Which of the following bind to cdk with cyclin and physically block the active site?
Antworten
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p21
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p27
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p19
Frage 13
Frage
How are the CDK inhibitors controlled?
Antworten
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Phosphorylation & degredation
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Phosphorylation & activation
Frage 14
Frage
How long is the bp sequence p53 binds to?
Antworten
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10 bp
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12 bp
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15 bp
Frage 15
Frage
Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
Antworten
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D-A-E-C-B
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D-A-C-E-B
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A-D-C-E-B
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B-A-D-E-C
Frage 16
Frage
How does p53 work in its active form?
Antworten
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As a monomer
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As a dimer
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As a tetramer
Frage 17
Frage
What does p53 bind to when active?
Antworten
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TATA boxes
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E-boxes
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Damaged DNA
Frage 18
Frage
What can cause the activation of p53?
Antworten
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Acetylation
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Phosphorylation
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Ionising radiation
Frage 19
Frage
What does p53 do if activated in G1?
Antworten
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Repairs DNA
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Reverts the cell back to G0
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Forces cell through mitotic cycle
Frage 20
Frage
What happens if p53 is activated after G1?
Antworten
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Bax is transcribed- it initiates apoptosis
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Bax is transcribed- It initiates S phase
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Bax is transcribed- It inhibits M phase
Frage 21
Frage
Where do mutations causing non-function tend to occur in p53?
Antworten
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The DNA binding domain
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The damaged DNA binding domain
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The signalling domain
Frage 22
Frage
How is p53 removed from the cell?
Antworten
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MDM2
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MDM
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MDM1
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