Flashcards
Proto-Oncogenes & Loss of Growth Control
Cards in this deck (16)
- 1OncogeneGene who's abnormal/mutated expression causes production of a malignant phenotype
- 2Proto-oncogeneCellular homologue from which oncogene is derived
- 3Tumor SuppressorEncodes a protein restricting cell growth
- 4Conversion to Oncogene - Deletion/Point mutationNormal amounts of hyperactive proteins
- 5Conversion to Oncogene - Gene FusionHyperactive fusion protein
- 6Conversion to Oncogene - Chromosome RearrangementVaries- Near a strong promoter, you get increased levels of normal protein
- 7Conversion to Oncogene - Gene ReplicationAmplified levels of normal protein
- 8No of Oncogene Classifications (At G0/G1 border4
- 9Competence FactorsIncreases production of cell cycle regulators
- 10Example of a Progression FactorEGF, PDGF, FGF
- 11Progression FactorsMust increase in conjunction with CF's, or the CF's are degraded and the cell remains in G0
- 12Example of Progression FactorsInsulin or IGF1
- 13Inhibitor FactorsPrevent accidental entering of mitotic cycle (must be absent for G1 to be entered)
- 14Example of Inhibitory FactorsTGFB
- 15Acutely Transforming RetrovirusesViruses containing a viral oncogene
- 16No of Class of Tyrosine Kinase9- each has different signalling molecules
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- Description
- Year 2 Flashcards on Proto-Oncogenes & Loss of Growth Control, created by gina_evans0312 on 02/12/2013.
- Created by
- gina_evans0312 · Dec 2013
- Updated
- Sep 16, 2016
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