Other Recruitment By Activated Tyrosine Kinase

gina_evans0312
Flashcards by gina_evans0312, updated more than 1 year ago
gina_evans0312
Created by gina_evans0312 about 8 years ago
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Year 2 Flashcards on Other Recruitment By Activated Tyrosine Kinase, created by gina_evans0312 on 12/02/2013.

Resource summary

Question Answer
p85 Regulatory domain of Phosphatidynosityl-3-Kinase
p110 Catalytic domain of Phosphatidynosityl-3-Kinase
Phosphatidynosityl-3-Kinase Family of lipid kinases recruited to active tyrosine kinase
Ras-GTP Required for full PI-3-K activation
Carbon of phosphatydinositol phosphorylated by PI-3-K 3rd
PTEN Reverses action of PI-3-Kinase
Phosphorylated membrane lipids PKB docking site
No of PKB domains 3
PKB-Plecstrin Homology Domain Binds molecule to phosphorylated lipid & recruits signalling molecules to membrane
Binding to membrane Required for activation
PDK1 & PDK2 Phosphorylate & activate PKB
mTOR Massive lipid/protein kinase complex that binds to PKB
Role of mTOR Part of DNA damage repair family
mTOR activates... Protein synthesis & cell growth
PDK1 & 2 are .... active Permanently
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