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103576
Paraventricular Leukomalacia
Description
Neuro and Psych Mind Map on Paraventricular Leukomalacia, created by sanex_16 on 22/05/2013.
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neuro and psych
neuro and psych
Mind Map by
sanex_16
, updated more than 1 year ago
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Created by
sanex_16
about 11 years ago
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Resource summary
Paraventricular Leukomalacia
Oligodendrocytes devoloping
OL progenitor, marker: NG2
Pre-OL: O4 and NG2
Immature OL; O4 and O1
Mature OL: O1 and MBP
Vulnerability of OLs
high ATP consumption
hydrogen peroxide production
Low Gluthione (antioxidant)
CP-AMPARs?
sphingolipids
ceramide
DR5 and CD95 clusters
OL's signalling
Organization
Form Na+ clusters on axons
Signalling
Receive excitatory input
Experimental models
Rodent OL are postnatal!
CNS hypoxiaischemia
Immune resonse: administrate bacterial lipopolysaccharides
Diagnosis
MRI, but not in unstable babies
Ultrasonography!
Prevention/treatments
Careful monitor PCO2 and other gases
Types and consequences
Focal vs. Diffuse
Focal
Microscopic
Macroscopic
Annotations:
About or less than 5% of babies with PVL
Cystic or non-cystic
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