3094603
Pregunta 1
Pregunta
What is the most common cancer in males?
Respuesta
-
Non Melanoma Skin Caner
-
Prostrate cancer
-
Lung cancer
-
Colorectal
Pregunta 2
Pregunta
What is the most common cancer in females?
Respuesta
-
Breast cancer
-
Non Melanoma Skin Cancer
-
Lung cancer
-
Colorectal cancer
Pregunta 3
Pregunta
How do Tobacco smoke and coal tar form cancer?
Respuesta
-
Forming aldehyde adducts
-
Forming DNA adducts
Pregunta 4
Pregunta
Exposure to what substances increases the liver cancer incidence?
Respuesta
-
Aflatoxin B1 and Hepatitits B
-
alcohol and tobacco
Pregunta 5
Pregunta
Protooncogene inheritance is classified as
Respuesta
-
Loss of function
-
Gain of function
-
Both
-
None of the above
Pregunta 6
Pregunta
Tumor suppressor gene inheritance is classified as?
Respuesta
-
Loss of function
-
Gain of function
-
Both
-
None of the above
Pregunta 7
Pregunta
In Familial cancer syndrome what is the gene that is mutated?
Respuesta
-
RET
-
MET(HGFR)
-
BCR
-
ABL
Pregunta 8
Pregunta
In Hereditary renal papillary carcinoma what is the gene that is mutated?
Respuesta
-
MET (HGFR)
-
RET
-
ABL
-
BCR
Pregunta 9
Pregunta
What is the translocation in follicular lymphoma
Respuesta
-
14:18
-
15:17
-
9:22
-
11:22
Pregunta 10
Pregunta
CML translocation is seen between what chromosomes?
Respuesta
-
9:22
-
15:17
-
11:22
-
14:18
Pregunta 11
Pregunta
What translocation is seen in Promyelocytic leukemia?
Respuesta
-
15:17
-
9:22
-
11:22
-
14:18
Pregunta 12
Pregunta
Translocation in Ewing's Sarcoma?
Respuesta
-
11:22
-
14:18
-
15:17
-
9:22
Pregunta 13
Pregunta
How does translocation cause cancer?
Respuesta
-
The novel product promotes proliferates like an oncogene
-
It makes a transcription factor that promotes proliferation
-
It makes a novel factor that inhibits apoptosis
-
None of the above
Pregunta 14
Pregunta
N-MYC is amplified in what tumor?
Respuesta
-
Neuroblastoma
-
Pheochromocytoma
-
Wilms tumor
Pregunta 15
Pregunta
In Knudson's 2 hit model what are the mechanisms for the second hit?
Respuesta
-
Loss of heterozygosity
-
Deletion
-
recombination
-
non-dysjunction
-
All of the above
Pregunta 16
Pregunta
Which of the following is not inherited by Autosomal Dominance?
Respuesta
-
Retinoblasotma
-
Li-Fraumeni Syndrome
-
Hereditary Breast cancer
-
Neurofibromatosis 1
-
FAP / HNPCC
-
None of the above
Pregunta 17
Pregunta
What are the mutations in FAP?
Respuesta
-
APC
-
BCR
-
ABL
Pregunta 18
Pregunta
What are the mutations in HNPCC?
Respuesta
-
MLH 1 and 3
-
MSH 2 and 6
-
PMS 1 and 2
-
All of the above
Pregunta 19
Pregunta
Wnt binds to Frizzled and activates dishevelled which in turn inhibits APC/Axin/GSK-3Beta
Respuesta
- True
- False
Pregunta 20
Pregunta
Beta Catenin is not phosphorylated so not destroyed so it accumulates and promotes proliferation
Respuesta
- True
- False
Pregunta 21
Pregunta
Microsatellite instability/ replication error positive is seen in HNPCC - true or false
Respuesta
- True
- False
Pregunta 22
Pregunta
What are the mutations that are seen in sporadic cancer?
Respuesta
-
PTEN
-
TGFBR2
-
SMAD4
-
WT1
-
All of the above
Pregunta 23
Pregunta
In Xeroderma Pigmentosum the most common nucleotide repair mechanism is excision endonuclease deficiency - true or false?
Respuesta
- True
- False
Pregunta 24
Pregunta
In Ataxia Telegectasia (ATM) mutation of what gene promotes proliferation?
Respuesta
-
p53
-
RB
-
myc
-
none of the above
Pregunta 25
Pregunta
Bloom syndrome - DNA helicase deficiency - true or flase
Respuesta
- True
- False
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