Cancer

Joe Wanford
Quiz by Joe Wanford, updated more than 1 year ago
Joe Wanford
Created by Joe Wanford about 5 years ago
4738
1

Description

A quiz reflecting on content covered on the 'genetics, mutation and cancer' page of the VGEC.

Resource summary

Question 1

Question
Mutations are a change in an organisms [blank_start]DNA[blank_end]. DNA mutations can result in a change in protein structure or not, these are referred to as non-[blank_start]synonymous[blank_end] and [blank_start]synonymous[blank_end] mutations respectively. Mutations can involve the [blank_start]substitution[blank_end] of one base for another, or the [blank_start]deletion[blank_end]/[blank_start]insertion[blank_end] of a base.
Answer
  • DNA
  • synonymous
  • synonymous
  • substitution
  • deletion
  • insertion

Question 2

Question
The reading frame of a piece of DNA determines which [blank_start]amino[blank_end] acids are assembled into a [blank_start]protein[blank_end] molecule. Insertions and deletions can cause [blank_start]frame[blank_end] shifts, [blank_start]changing[blank_end] the codons downstream of the mutation.
Answer
  • amino
  • protein
  • frame
  • changing

Question 3

Question
Mutations are responsible for over 4000 [blank_start]genetic[blank_end] diseases in humans. Some of these diseases stem from just a single [blank_start]nucleotide[blank_end] mutation. One example of this is in cystic [blank_start]fibrosis[blank_end], which is caused by mutation of the gene encoding the CFTR protein. One of the most well known genetic diseases worldwide is [blank_start]cancer[blank_end].
Answer
  • genetic
  • nucleotide
  • fibrosis
  • cancer

Question 4

Question
Cancer is caused by cells losing their ability to control cell [blank_start]division[blank_end], to undergo programmed cell [blank_start]death[blank_end] and many other hallmarks. Cancer progression occurs following a sequence of [blank_start]mutations[blank_end] in [blank_start]tumour[blank_end] [blank_start]suppressor[blank_end] [blank_start]genes[blank_end] and proto-[blank_start]oncogenes[blank_end].
Answer
  • division
  • death
  • mutations
  • tumour
  • suppressor
  • genes
  • oncogenes

Question 5

Question
Appropriately label the diagram below
Answer
  • Cancerous cell
  • Healthy cell
  • Mutations in oncogenes
  • Mutations in TSGs
  • Mutations in oncogenes and TSGs
  • Healthy growth
  • Malignant cells
  • Healthy cells
  • Cells with a single mutation

Question 6

Question
The likely hood of cancer is increased if you are exposed to [blank_start]mutagens[blank_end]. This is because mutagens increase the [blank_start]mutation[blank_end] [blank_start]rate[blank_end] of your cells.
Answer
  • mutagens
  • mutation
  • rate
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