456616
Descripción
Test por gina_evans0312, actualizado hace más de 1 año
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Creado por gina_evans0312
hace más de 10 años
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Pregunta 1
Pregunta
What is done in pairwise alignment?
Respuesta
-
Two sequences are stuck on top of each others and the common areas lined up
-
Two sequences are aligned from the beginning and their similarity analysed
-
Two sequences are aligned and their similarity analysed
Pregunta 2
Pregunta
Local alignment assigns correspondences to all residues in the sequence, leaving gaps if necessary
Respuesta
- True
- False
Pregunta 3
Respuesta
-
An indel
-
A mismatch
Pregunta 4
Respuesta
- True
- False
Pregunta 5
Pregunta
What can sequence identity be used for?
Respuesta
-
DNA sequence
-
Amino acid sequence
-
Gene sequence
Pregunta 6
Pregunta
Sequence identity can be how specific?
Respuesta
-
Global
-
Local
Pregunta 7
Pregunta
What are GAPS?
Respuesta
-
Spaces in part of the sequence that allows other areas to align better
-
Areas with a high density of indels
-
Proteins that align when sequences are swapped over
Pregunta 8
Pregunta
What is the scoring system that determines an optimal alignment?
Respuesta
-
+2 Match -1 Indel -2 Mismatch
-
+2 Mismatch -1 Match -2 Indel
-
+2 Match -1 Mismatch -2 Indel
Pregunta 9
Pregunta
Needleman and Wunsch algorithms find the highest scoring path across a matrix
Respuesta
- True
- False
Pregunta 10
Respuesta
-
Light- Remote homologues Dark - Close homologues
-
Light- Close homologues Dark- Remote homologues
Pregunta 11
Pregunta
PAM matrices used varies depending on the S.I
Respuesta
- True
- False
Pregunta 12
Pregunta
PAM250 scoring is used for remote homologues
Respuesta
- True
- False
Pregunta 13
Pregunta
In PAM250 scoring, scores are given based on what?
Respuesta
-
The residue rarity
-
The properties of the replacing residue- i.e. is one small hydrophobic residue replacing another
Pregunta 14
Pregunta
What does BLAST stand for?
Respuesta
-
Basic Loci Alignment Search Tools
-
Basic Loci Alignment Sequencing Tools
-
Basic Local Alignment Search Tools
Pregunta 15
Pregunta
What is different about BLAST techniques?
Respuesta
-
The compare residue 'words' instead of single residues/bases
-
They work in areas of less than 50bp long
-
They cover the whole genome very rapdily
Pregunta 16
Pregunta
A 'word' is 3bp or 11 aa long
Respuesta
- True
- False
Pregunta 17
Pregunta
Once the words have been found in the sequence, they are compared to the database- why?
Respuesta
-
To find exact matches
-
To find evolutionary relationships
-
To detect how common the words are
Pregunta 18
Pregunta
An E value is expectation, not probability
Respuesta
- True
- False
Pregunta 19
Pregunta
What is the range and significance for the E value?
Smaller values are more likely
Respuesta
-
0-10
-
1-2
-
0-1
-
0.5
-
5
-
0.005
Pregunta 20
Pregunta
The E value is the probability of getting a result by change in a database of this size
Respuesta
- True
- False
Pregunta 21
Pregunta
What is the difference between P and E values
Respuesta
-
Both are values for 'What is the probability of getting this result by chance alone?', but P accounts for database size
-
Both are values for 'What is the probability of getting this result by chance alone?', E accounts for database size
Pregunta 22
Pregunta
In P values, <0.05 is significant
Respuesta
- True
- False
Pregunta 23
Pregunta
P value relies on a normal distribution
Respuesta
- True
- False
Pregunta 24
Pregunta
What are the limits of P?
Respuesta
-
0-0.1
-
0-1
-
0-10
Pregunta 25
Pregunta
An E of 4 is equal to - in a database of this size, I could get 4 matches by chance alone
Respuesta
- True
- False
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