Other Recruitment By Activated Tyrosine Kinase

Pregunta	Respuesta
p85	Regulatory domain of Phosphatidynosityl-3-Kinase
p110	Catalytic domain of Phosphatidynosityl-3-Kinase
Phosphatidynosityl-3-Kinase	Family of lipid kinases recruited to active tyrosine kinase
Ras-GTP	Required for full PI-3-K activation
Carbon of phosphatydinositol phosphorylated by PI-3-K	3rd
PTEN	Reverses action of PI-3-Kinase
Phosphorylated membrane lipids	PKB docking site
No of PKB domains	3
PKB-Plecstrin Homology Domain	Binds molecule to phosphorylated lipid & recruits signalling molecules to membrane
Binding to membrane	Required for activation
PDK1 & PDK2	Phosphorylate & activate PKB
mTOR	Massive lipid/protein kinase complex that binds to PKB
Role of mTOR	Part of DNA damage repair family
mTOR activates...	Protein synthesis & cell growth
PDK1 & 2 are .... active	Permanently

Resumen del Recurso

	Creado por gina_evans0312 hace casi 13 años