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Tumor Suppressors

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Year 2 Quiz on Tumor Suppressors, created by gina_evans0312 on 03/12/2013.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
What is the role of the Rb Susceptibility gene?
Answer
  • Nuclear transcription factor
  • Nuclear phosphatases
  • Nuclear phosphorylases

Question 2

Question
What protein does Rb bind to?
Answer
  • E2F
  • FF2
  • EF2

Question 3

Question
What is the role of the protein bound to Rb?
Answer
  • Transcription factor
  • Kinase
  • Phosphatase

Question 4

Question
What are the target genes of the Rb bound protein?
Answer
  • dNTP producing genes
  • Transcription factor producing genes
  • Growth factor producing genes

Question 5

Question
How is Rb phosphorylated and deactivated?
Answer
  • By Cyclin
  • By CDK
  • By a cyclin/CDK dimer

Question 6

Question
What protein phosphorylates CDK?
Answer
  • CAK
  • CAD
  • CAB

Question 7

Question
Which forms first during G1?
Answer
  • CDK/Cyclin D
  • CDK/Cyclin E

Question 8

Question
What causes the production of Cyclin/CDK E &D?
Answer
  • Jun Activity
  • AP1 Activity
  • Myc Activity

Question 9

Question
Which is required to activate E2F?
Answer
  • Cyclin/CDK D
  • Cyclin/CDK E
  • Both
  • Neither

Question 10

Question
Name 3 CDK inhibitors
Answer
  • p13
  • p21
  • p12
  • p16
  • p27
  • p19

Question 11

Question
Which of the following binds to CDK, & twists its head to block the active site?
Answer
  • p16
  • p12
  • p19

Question 12

Question
Which of the following bind to cdk with cyclin and physically block the active site?
Answer
  • p21
  • p27
  • p19

Question 13

Question
How are the CDK inhibitors controlled?
Answer
  • Phosphorylation & degredation
  • Phosphorylation & activation

Question 14

Question
How long is the bp sequence p53 binds to?
Answer
  • 10 bp
  • 12 bp
  • 15 bp

Question 15

Question
Put the following p53 domains in order A- Signalling Domain B- Damaged DNA binding domain C-Oligomerization Domain D- Activation Domain E- DNA binding domain
Answer
  • D-A-E-C-B
  • D-A-C-E-B
  • A-D-C-E-B
  • B-A-D-E-C

Question 16

Question
How does p53 work in its active form?
Answer
  • As a monomer
  • As a dimer
  • As a tetramer

Question 17

Question
What does p53 bind to when active?
Answer
  • TATA boxes
  • E-boxes
  • Damaged DNA

Question 18

Question
What can cause the activation of p53?
Answer
  • Acetylation
  • Phosphorylation
  • Ionising radiation

Question 19

Question
What does p53 do if activated in G1?
Answer
  • Repairs DNA
  • Reverts the cell back to G0
  • Forces cell through mitotic cycle

Question 20

Question
What happens if p53 is activated after G1?
Answer
  • Bax is transcribed- it initiates apoptosis
  • Bax is transcribed- It initiates S phase
  • Bax is transcribed- It inhibits M phase

Question 21

Question
Where do mutations causing non-function tend to occur in p53?
Answer
  • The DNA binding domain
  • The damaged DNA binding domain
  • The signalling domain

Question 22

Question
How is p53 removed from the cell?
Answer
  • MDM2
  • MDM
  • MDM1
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