White Adipose Tissue Hormones

Pregunta	Respuesta
TNF-Alpha & IL6- Role	Proinflammatory cytokines that also confer insulin resistance
TNF-Alpha & IL6- Release	In the absence of inflammation
TNF-Alpha & IL6- Overexpression	In obesity, as there is more WAT, so more insulin resistance
TNF-Alpha & IL6- Method Of Action	P the serine residue of IRS1, so it cannot respond to Insulin receptor activation
TNF-Alpha & IL6- Inhibits	Insulin response & adiponectin
Resistin- Role In Humans	Unknown
Resistin- Role in Mice	Increased insulin resistance and decreased insulin stimulated glucose transport
Adiponectin- Role	Increased insulin sensitivity
Adiponectin- Release	Increased in weight loss, decreased in the obese/IL6/TNF-Alpha secretion
Adiponectin- Method of Action	Increased FA oxidation, decreased intracellular lipids and FA, decreased hepatic glucose poduction
Leptin- Role	Appetite suppressant, increases utilisation
Leptin- Release	Inc when fat stores are high, and vice versa
Leptin- Method of Action	Secretion of neuropeptide gamma
Leptin- Ineffective Gene Effects	Obesity and insulin resistance
Leptin- Overexpression	Insulin resistance

Resumen del Recurso

	Creado por gina_evans0312 hace alrededor de 10 años