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1Osteoblasts secrete ______, which helps in the formation of ______.alkaline phosphatase; hydroxyapatite
2Which transcription factor is required for osteoblast differentiation?Runx2
3Which signalling pathway is essential to osteoblast differentiation?Wnt signaling pathway
4osteocytes are derived from _____osteoblasts
5How does the Wnt pathway relate to RUNX2?activates RUNX2, which leads to osteoblast differentiation
6Osteoclats secrete ______ & _____.TRAP; Cathepsin K
7TRAPspecial type of acid phosphatase which helps to catalyze the release of calcium and phosphorous from bone; secreted by osteoclasts
8Cathepsin Kprotease that degrades collagen; secreted by osteoclasts
9RANKLreceptor activator of NFkB ligand which binds to and activates RANK on monocytes; promotes bone resorption
10the mesenchymal stem cell is the precursor to ________osteoblasts
11the hematopoietic precursor cell differentiates into ________osteoclast
12What system of bone cells is responsible for the active remodeling of bone?bone formation unit
13T or F: Bones remodel sporadically.False; bones are always actively remodeling
14During which situations do bones form?early development
before adulthood
remodeling
fractures healing
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