Fichas
AG2 Blockers
Fichas del conjunto (10)
- 1—LOSARTAN
Very selective angiotensin receptor antagonist
works in AT1 on AG2
orally efficacious
50 mg qd (maintenance 25-100mg)
effective in reducing ACE cough - 2—VALSARTAN
Angiotensin Receptor Antagonist
predominantly AT1
80-320mg/day
- 3—Irbesartan
150-300mg/day
- 4—CANDESARTAN
as low as 2mg/day (typically 8-32mg)
good bioavailability
cascading prodrug
67% feces 33% urine
dont need renal fnc to elim
- 5—TELMISARTAN
carboxylate gives it affinity
a little more potent
20-80mg/day
- 6—EPROSARTAN
AT1 blocker
400-800mg/day
no particular benefit
- 7—OLMESARTAN
Cascading prodrug
used w/o adjustment in renal or hepatic problems
50/50 in urine and deces
.3-.5% angioedema (greater with ACE inhibitors) but can be life threatening
- 8—OMAPATRILAT
- 9—ALISKIREN
150-300mg/day orally
or in cominations
not in 2nd and 3rd trimester (affects kidney development in fetus)
- 10—RESERPINE
Inhibition of active transport of NE into storage vesicles
post ganglionic sympathetic inhibition
depression is a big side effect