Autism

Advances in understanding the pathophysiology of autism spectrum

disorders

Autism Spectrum Disorder

Is

Common disorder in the neurodevelopment

It is characterized by

Language and communication abnormalities

Impaired social interaction

stereotypical behavior

Different theories

Modern theories

Models induced by environmental factors

Neural connectivity:

By the deterioration in the neural connectivity and damaged synaptogenesis can to have relation with ASD

Impaired neural migration:

During the prenatal period there is a mutation of a gene that Can be related with ASD

Impaired synaptogenesis and dendritic morphogenesis:

The altered synaptogenesis is a important characteristics of ASD

The broken mirror theory:

The limited development of mechanics in mirror that can to allow the recognition and comprehension of actions and emotions of other persons can to determine some aspects of ASD

Biological agents:

Maternal infectionso or different diseases can trigger similar symptoms to ASD

Chemical agents:

There is greater risk by teratogenic factors or valproic acid during pregnancy

Models induced by brain lesion/damage:

Brains studies demonstrated that some regions have relation with the pathogenesis de ASD

Models induced by genetic modifications:

Scientists are looking for the combination of genetic factors and ambient factors for see models of ASD

Conclusions:

it is necessary more investigation for identify the etiology of Autism spectrum disorder

Bibiography:

Yenkoyan,K., Grigoryan,A., Fereshetyan,K., & Yepremyan,D. (2017). Advances in undestanding the Phatophysiology of Austism Spectrum Disorders . Behavioural Brain Research, 331, 92-101.