Glycoconjugates

Glycoconjugates

1. its meanly component is glucose, they are synthesized in ER, Golgi

   • they come from manose, glucose, galactose,
   • they have to be marked, through hexokinase, isomerase changes their isoforms, and after have to be added UDP
     • The same protein can be glycosylated in different ways depending on the tissue
   • Glycosidic bonds can be alpha or beta

2. gives heterogenicity

   • gives protectión, variability, especivity
     • provide structural stability to the skeleton or extracellular matrix
       • Glycosaminoglycans
         • they attract water with great force
         • facilitate cell migration
         • chondritin sulfate
         • Homeostasis
         • heparan sulfate
         • heparin
       • glycoproteins
         • protein bound to one or more oligosaccharides
         • structural
         • inmun sistem (Ig)
         • protect from proteolysis
         • O-GlcNAc
         • synthesis of glucose, Acetil CoA
       • Proteoglycans
         • linked by electrostatic interactions
           • are made from high molecular weight amino sugars
             • They may be
               • syndecans
               • beta-glucans
               • aggrecans

3. The bad glycosylation of these biomolecules may cause serious diseases such as cancer, neurodegeneration, diabetes and congenital disorders.

4. The lack of degradation or accumulation of these can cause mucopolysaccharidosis.