Cholesterol Metabolism

Cholesterol Metabolism

1. Present in

   • Tissues
     • Anfipatic lipid
       • Fundamental compound of membranes
         • Permeability
         • Correct Flow
       • Forerunner
         • Steroids
           • Sexual Hormones
           • Corticosteroids
           • Biliar acids
           • D Vitamin
   • Plasma

2. Regulation

   • The target molecule
     • HMG CoA
       • Inhibited
         • Mevalonate
         • Cholesterol
           • Axtivation
             • SREBP
               • Daily Cycle
       • Stimulated
         • Insulin
         • Tyroid Hormone
   • Reductase Kinase
     • KInase Kinase Reductase
       • Kinase Reductase (activated)
         • Phosphatase Protein
           • Insulin
           • Inhibitor
             • cAMP
               • Glucagon
             • 1 Phosphate
         • HMG CoA Reductase (NOT ACTIVATED)
           • Phosphatase protein
             • HMG CoA Reductase (ACTIVATED)
               • Inhibitor
                 • Oxisteroles
                   • Cholesterol

3. Synthesis

   • Sources
     • Endogen
       • Inner synthesis inside the liver
         • 700 mg/per day
     • Exogen
       • Dietary intake
         • Can stimulate the inner synthesis
   • Biosynthesis
     • 5 steps formation
       • Acetil CoA
         • Tiolase
           • Acetoacetil CoA
             • HMG CoA synthase
               • 3 hidroxi 3 metilglutaril- CoA (HMG CoA)
                 • HMG CoA reductase
                   • Mevalonate
                     • Mevalonate kinase
                       • Mevalonate 5 phosphate
                         • Mevalonate 5 diphosphate
                           • Mevalonate 3 phoshpho 5 diphosphate
                             • Isopentil diphosphate
                               • Geranil diphosphate
                                 • Escualeno
                                   • Cyclization
                                     • Main steroid
                                       • Lanosterol
                                         • Cholesterol
                         • Phosphomevalonate kinase
                   • Statines

4. Transportation

   • Through lipoproteins
     • Colesteril esterj
   • Liver
     • • Billiar Conduct
         • Intestine
           • Dietary intake
           • Chylomicrons
             • Tg
             • Ce
             • Cholesterol
             • IDL
               • LDL
                 • LDL RECEPTOR
                 • ce / cholesterol
                 • VLD
             • LRP RECEPTOR
       • Billiar acids
         • Billiar acids
       • HDL
         • Recollect cholesterol
           • Periferic tissues