Mapa mental
T cells
Contenido del mapa
T cells
Basics
- Develop in Thymus
- live 6 months to 20 + years
- ~80% of recirculating pool
CD4/CD8
- Promote adhesion and signal transduction for T cell activation
- CD4 with beta2
- CD8 with alpha3
TCR
- TCR, CD3 complex, Zeta proteins
- TCR gamma delta
- TCR alpha beta
- Variable, constant, hinge region
- 3 CDRs (hypervariable regions)
- CDR3- most diverse
- 50K+ and clonotypic
- TCR, CD3 complex, Zeta proteins
Other Co-Stimulatory
- CD28
- always expressed
- part of Signal 2
- Ligand is B7 on proAPCs
- CD2
- on mature T cells
- Ligand is CD58 (LFA-3)
- on ProAPCs or target cells
- T cell signal transducer
- Intercellular adhesion molecule
- CD11aCD18
- Ligand CD54 (ICAM-1)
- on APCs and Target cells
- promotes binding of T cells to endothelial cells during T cell extravasation
- Ligand CD54 (ICAM-1)
- CD28
Información
- Descripción
- Attempt to map out T cells and related cue words to try to present the 'big picture'....not covered in this mind map: recombinase enzympes, gene rearrangement, junctional diversity, selection of thymocytes, T cell subsets...
- Creado por
- Marjorie P · nov 2014
- Actualizado
- 19 feb 2016
- Visitas
- 14
- Valoración