Endoplasmic Reticulum

Endoplasmic Reticulum

1. Endoplasmic reticulum is a substructure present in the eukaryotic cells

2. Structure

   • reticulum rough endosplásmico
     • Protein synthesis and storage
       • Glycosylation of proteins
     • located near the cell nucleus
   • Reticulum smooth endosplásmico
     • Lipid synthesis
       • Muscle contraction
         • detoxification
           • Glucose release
     • Located away from the core

3. central role in lipid and protein biosynthesis.

4. Resident protein

   • Protein Disulfide Isomerase
     • catalyzes the oxidation of free sulfhydryl groups on cysteines to form disulfide bonds.
   • BiP
     • Recognizes incorrectly folded proteins
       • Atracts proteins after it’s traduction to the inside of the ER.