Drugs

Drugs

1. P-gp

   • Substrates
     • Analgesics: Morphine (MS CONTIN)
     • Antibiotics
       • Erythromycin
       • Clarithromycin
       • Metronidazole
       • Tetracycline
       • Doxycycline
     • Anticoagulants (NOACs)
       • Apixaban
       • Dabigatran
       • Rivaroxaban
     • Antineoplastic Drugs
       • Docetaxel
       • Etoposide
       • Methotrexate
       • Vincristine
     • Anti-Seizure Meds
       • Carbamazepine (Tegretol)
       • Phenytoin (Dilantin)
     • Antiviral
       • HIV MEDS: Protease inhibitors
       • Hep C Meds
         • Ledipasvir + Sofosbuvir (Harvoni)
         • Sofosbuvir + velpatasvir (Epclusa)
           • NOTE: ONly Velpatsvir is a 3A4 Substrate
     • Cardiac Meds
       • Digoxin
       • Quinidine
     • Calcium Channel Blockers (CCBs)
       • Amlodipine
       • Diltiazem
     • HMG-CoA Reductase Inhibitors
       • Lovastatin (Mevecor)
       • Atorvastatin (Lipitor)
       • Pravastatin
     • Steroids: Methylprednisolone (Solu-Medrol)
     • Transplant Meds/Calcineurin inhibitors:
       • Cyclosporine
       • Tacrolimus (Prograf)
     • Azoles
       • Litraconazole (Sporanox)
     • H2 Receptor Antagonist
   • Inducers
     • Anti-seizure Meds
       • Phenobarbital
     • AntiViral-HIV Meds: Protease Inhibitors
       • Indinavir (Crixivan)
       • Nelfinavir (Viracept)
       • Ritonavir (Norvir)
       • Saquinnavir (Invirase)
       • Tipranavir (Aptivus)
     • Azoles
       • Clotrimazole (Mycelex)
     • Blood Pressure Meds
       • Prazosin (Minipress)
       • Spironolactone (Aldactone)
     • Psych Meds: Phenothiazines
     • Vitamin A Metabolite: Retinoic Acid (Accutane)
     • Steroids
       • Dexamethasone (Decadron)
   • Inhibitors
     • Analgesics
       • Meperidine
       • Methadone
       • Pentazocine
     • Antibiotics
       • Azithromycin
     • Azoles
       • Ketoconazole (Nizoral)
       • High Dose Fluconazole
     • BP Meds
       • Captopril (Capoten)
       • Carvedilol (Coreg)
       • Diltiazem (Cardizem)
       • Doxazosin (Cardura)
       • Reserpine
       • Verapamil (Calan)
     • Ergot Alkaloid: Bromocriptine (Cyclocet)
     • HIV MEDS
       • Lopinavir + Ritonavir (Kaletra)
     • Lipid Meds
       • Fluvastatin (Lescol)
       • Simvastatin
     • Transplant Meds
     • Cancer Meds
       • Tamoxifen
     • Steroid Hormones
       • Progesterone

2. CYP3A4

   • Inhibitors
     • Analgesics: Suboxone
     • Antibiotics
     • Calceneurin-Transplant Med
     • Grapefruit Juice
     • Cardiac Meds
       • Amiodarone
     • Azoles
     • Calcium Channel Blockers
       • Nifedipine
       • Verapamil
     • H2 Blockers
       • Cimetidine (Tagamet)
       • Ranitidine
     • TB Meds: Isoniazid
     • Psych Med
       • Fluoxetine (Prozac)
       • Fluvoxamine
       • Haloperidol
   • Inducers
     • Herbal: St. John's Wort
     • Antiviral HIV Meds: Protease Inhibitors CYP3A4 ALL SAME
     • Analgesics: Barbiturates
     • Antifungal: Griseofulvin
     • Diabetes Meds:
       • Pioglitazone
       • Troglitazone (Discontinued recently)
       • Rosiglitazone
     • Steroids: Glucocorticoids
     • Anti-seizure Meds
       • Ethosuximide
       • Primidone (Mysolin
     • TB Med: Rifampin
   • Substrates
     • Anesthetic: Lidocaine
     • Sleep Med: Zolpidem (Ambien)
     • Transplant Meds
     • Antibiotics
     • Anti-Cancer Meds
     • Analgesics
       • Acetaminophen
       • Celecoxib
       • Cocaine
       • Codeine
       • Fentanyl
       • Tramadol
     • Asthma Med: Theophylline
     • Gout Med: Colchicine
     • Anticoagulants
       • Coumadin
     • Antihistamines
       • Chlorpheniramine
       • Non-Sedating antihistamines
     • Anti-HCV Drug
     • Benzodiazepines
       • Alprazolam
       • Clonazepam
       • Diazepam
       • Midazolam
       • Triazolam
     • Cardiac Meds
     • HMG CoA Reductase Inhibitors
     • Psych Meds: SSRI's
     • Steroids
       • Hydrocortisone
     • Anti-Seizure Meds
     • Calcium Channel Blockers

3. CYP2D6

   • INDUCERS
   • SUBSTRATES
     • Aricept
     • Hydrocodone
     • Oxycodone
   • INHIBITORS
     • Desipramine
     • Dephenhydramine/Benadryl
     • Paroxitine
     • Bupropion
     • Phenothiazines
     • Risperidone
     • Proranolol

4. CYP2C9

   • INHIBITOR
     • Bactrim
     • Valproic Acid (Depakote/Depakene
   • SUBSTRATES
     • Glipizide

5. CYP2C19

   • SUBSTRATES
     • Anti-Depressants (MAO-I's)
     • Ibuprofen
     • Clopidogrel
   • INHIBITORS
     • Omeprazole/Prilosec

6. CYP1A2

   • INDUCERS for CYP1A2, 2C9, 2C19
     • CYP1A2 ONLY: Broccoli, Brussel Sprouts, Tobacco
   • INHIBITOR
     • Ciprofloxacin
     • TriCyclic Antidepressants
   • SUBSTRATES
     • Caffeine
     • Clozapine
     • Naproxen
     • Olanzapine