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PHSI3011 05-2 Maintenance of Bone Health

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1If Resorption < Formation:
1. A↑ Bone Mass
2. B↓ Bone Mass
2Which of the following are bone mass determinants:
1. AGenetics
2. BAge
3. CMechanical loading
4. DProtein intake
5. ECalcium intake
6. FVitamin D
7. GSex steroids
8. HVitamin C
3Sclerostin is released by which of the following?
1. AOsteocytes
2. BOsteoblasts
3. COsteoclasts
4. DLining Cells
4Sclerostin __________ Wnt signalling in Osteoblasts/Osteocytes
1. AInhibits
2. BStimulates
5With deformity of bone (on loading), sclerostin secretion:
1. AIncreases
2. BDecreases
6SOST = ??
1. ASclerOSTin
2. BStimulated by OSTeocyte
7Obligatory urine Calcium loss is [blank_start]__________[blank_end] mg/d (although [blank_start]__________[blank_end] after menopause).
1. A150-200
2. B1000
3. C25
4. D300
5. EMore
6. FLess
8Recommended daily allowance for calcium changes according to age, but broadly mostly around:
1. A1000
2. B70
3. C150-200
4. D700
5. E2000
6. F1500-2000
7. G25
8. H300
9Vitamin D [blank_start]__________[blank_end] gut Calcium absorption:
1. ADecreases
2. BIncreases
10A non-Calcium-rich diet will usually have approximately [blank_start]__________[blank_end] mg/d Calcium. This is [blank_start]__________[blank_end]% of recommended intake.
1. A300
2. B1000
3. C150-200
4. D30
5. E15-20
6. F25
7. G100
8. H70

11True or false: Exposure to the sun is [normally] our main source of Vitamin D.
1. AVerdadero
2. BFalso
12True or false: Diet is [normally] our main source of Vitamin D.
1. AVerdadero
2. BFalso
13What’s the recommended daily intake of Vitamin D?
1. A1000IU (25μg)
2. B25IU (1000μg)
14Which of the following accelerates Vitamin D degradation?
1. ASome medications
2. BLOW Calcium intake
3. CHIGH Calcium intake
4. DHIGH PTH
5. ELOW PTH
15Which of the following groups are commonly associated with increased risk of Vitamin D deficiency?
1. AGeriatric admissions to hospital
2. BDark-skinned people, especially with modest dress
3. CObese people
4. DFair skinned people with severe tan
5. EFair skinned people who avoid sun because of skin cancer risk
6. FOffice workers
7. GNight shift workers
8. HFarmers
16In a study of 100 office workers in Sydney, sunscreen users had [blank_start]__________[blank_end] Vitamin D levels compared to non-users.
1. AHigher
2. BLower
17How does Vitamin D help bone health?
1. AIncreases gut Calcium absorption
2. BFacilitates bone mineralisation
3. CImportant for muscle function
4. DPermits release of bone stores of Calcium
5. EIt doesn’t
18Vitamin D deficiency leads to increased bone turnover. Severe Vitamin D deficiency leads [primarily] to?
1. AOsteomalacia
2. BOsteoporosis
3. CBoth of the above
4. DNeither of the above
19Adequate levels of [blank_start]__________[blank_end] are needed to maximise Calcium absorption and [blank_start]__________[blank_end] ParaThyroid Hormone (PTH).
1. A25OHD
2. B25HD
3. C25OD
4. D2OH5D
5. E20O5HD
6. FSuppress
7. GIncrease
2025OHD = ??
1. A25(OH) vitamin D
2. B1,25(OH) vitamin D
3. C1,25(OH)2 vitamin D
4. D25(OH)2 vitamin D
21Severe CALCIUM deficiency can lead to:
1. AOsteoporosis
2. BOsteomalacia
3. CRickets
22Severe VITAMIN D deficiency can lead to Osteomalacia/Rickets. Are they the same thing?
1. AYeah
2. BNah
23Which of the following helps to maintain normal balance between bone formation and resorption:
1. AAndrogens
2. BOestrogens
3. CBoth of the above
4. DNeither of the above
24True or False: Oestrogens help to keep bone cells alive.
1. AVerdadero
2. BFalso
25True or False: Androgens help to keep bone cells alive.
1. AVerdadero
2. BFalso
26True or false: Anorexia leads to weak bones solely through nutrient deficiency.
1. AVerdadero
2. BFalso
27Glucocorticoids (Cortisone etc) are catabolic at pharmacologic doses. Where does each manifestation occur?
↓ Calcium absorption in the [blank_start]__________[blank_end];
↑ Calcium losses in the [blank_start]__________[blank_end];
↓ IGF-1 in the [blank_start]__________[blank_end];
1. AGut
2. BKidney
3. CBone
28Protein intake helps:
1. ABone function
2. BMuscle function
3. CBoth of the above
4. DNeither of the above
29If a diet contains inadequate Calcium to replace urinary losses, what happens?
1. ARaid bones for Calcium
2. BNothing

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Descripción: PHSI3011 05-2 Maintenance of Bone Health
Autor: Usuario eliminado
Idioma: English
Visitas: 18
Historial: Creado el 8 nov 2017 · actualizado el 10 nov 2017
Etiquetas: phsi3011 w05 mason physiology 2017 bone el usuario ha eliminado su información de asignaturas
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PHSI3011 05-2 Maintenance of Bone Health

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