Task 5

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TMS and fMRI

1. With TMS and fMRI researchers could find BOLD signal not only at the stimulation site but also in remote brain structures.

2. Remote BOLD effects can be very different for different sites considered to be within the same overall network.

Concurrent TMS-fMRI now makes it possible to investigate context-dependence of functional interactions within extended networks of remote but interconnected brain areas, while varying stimulation or task-state.These results support the view that engagement in active motor interactions between (pre-) motor structures in opposite hemispheres, so that neural activity elicited in one of these structures is transmitted to other interconnected regions of the network currently engaged in implementing the motor behaviour, in a different way when acting than when in a passive state.