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MD5 - 6 Chemical Degradation by Oxidation and Hydrolysis

Mer Scott 9 preguntas

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Preguntas del test (9)

  1. 1Select the two most common chemical degradation methods.
    1. AOxidation
    2. BHydrolysis
    3. CPhotolysis
    4. DIsomerisation
    5. EPolymerisation
  2. 2A negative slope in a pH-rate profile indicates specific [blank_start]base[blank_end] catalysis, while a positive slope indicates specific [blank_start]acid[blank_end] catalysis. A water reaction can contriute to a flat part ([blank_start]pH independent part[blank_end]) in the intermediate range of the curve, where specific catalysis still continues but is [blank_start]less prominent[blank_end] than the water reaction.
    1. Aacid
    2. Bbase
    3. CpH independent part
    4. Dless prominent
    5. Emore prominent
    6. FpH dependent part
  3. 3Label the rule of thumb factors with temperature change.Imagen de la pregunta 3
    1. Ax2
    2. Bx4
    3. Cx8
    4. Dx4 (2)
    5. Ex16
    6. Fx64
  4. 4A drug with an ionised and unionised form will have six degradation rate constants, k, because each form can undergo acid catalysis, base catalysis, and a reaction with water.
    1. AVerdadero
    2. BFalso
  5. 5Generally ionisation gives rise to more [blank_start]complex[blank_end] pH-rate profiles (not simply V-shaped curve), but [blank_start]not all reactions[blank_end] are necessarily [blank_start]significant[blank_end]. We can determine the pH-rate profile [blank_start]experimentally[blank_end] by keeping a constant temperature and changing the pH to measure rate constants.
    1. Acomplex
    2. Bnot all reactions
    3. Csignificant
    4. Dexperimentally
  6. 6B-lactams are hydrolysable groups.
    1. AVerdadero
    2. BFalso
  7. 7Amides are ionisable groups.
    1. AVerdadero
    2. BFalso
  8. 8If procaine has a hydrolysable group and two ionisable groups, and so can be unionised, mono-protonated or di-protonated, how many potential hydrolysis reactions does it have?
    1. A9
    2. B6
    3. C12
  9. 9Generally, general acid/base catalysis will lead to [blank_start]slope deviation[blank_end] (different from +/- 1) eg. buffer catalysis. Other factors, such as [blank_start]ionic strength[blank_end], may also
    lead to apparent deviations in the pH-rate profile.
    Electrolytes are often added to formulations to control [blank_start]tonicity[blank_end], and they [blank_start]increase[blank_end] the ionic strength of the formulation.
    1. Aslope deviation
    2. Bionic strength
    3. Ctonicity
    4. Dincrease

Información

Descripción
(Medicines) PHCY211 Test sobre MD5 - 6 Chemical Degradation by Oxidation and Hydrolysis, creado por Mer Scott el 12/05/2018.
Idioma
English
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