Anthelmintics

Stimulate the nicotinic acetylcholine receptors. It will depolarise the receptors but then they will become unresponsive to the stimuli and will no longer depolarise. This paralysed the worm. This mechanism of action describes which drug?

Tick the administration routes of macrocyclic lactones

Cyclooctadesi[blank_start]peptides[blank_end] Example: Emodepside Mechanism of action: [blank_start]Ach[blank_end] release inhibited = flaccid paralysis Spectrum: [blank_start]adult nematodes[blank_end]

[blank_start]Salicylanides and Nitroxynil[blank_end]: uncouples oxidative phosphorylation Spectrum: trematodes [blank_start]Clorsulon[blank_end]: inhibits 3-phopshoglycerate kinase & phospho-glycero-mutase which blocks the glycolytic pathway Spectrum: Adult liver fluke [blank_start]Praziquantel[blank_end]: tetanic contraction of parasites musculature -> vacuolisation of the syncytial tegument Spectrum: cestodes and trematodes

Write the group with the correct name of the anthelmintic Levamsoles: [blank_start]2[blank_end] Macrocyclic Lactones: [blank_start]3[blank_end] Multi-actives: [blank_start]5[blank_end] Benzimidazoles: [blank_start]1[blank_end] Amino acetonitriles: [blank_start]4[blank_end] The others are: praziquantel, salycylanides/ clorsulon, cyclooctadepsipeptides

Macrocyclic lactones Chloride influx causes [blank_start]hyper[blank_end]polarisation of the pos synaptic cell and interferes with the neurotransmission of the parasite = flaccid paralysis [blank_start]Long[blank_end] half life Generally persistent Spectrum: [blank_start]Endectocide[blank_end]

Monepantel: targets the nematode specific subunit of the [blank_start]nicotinic[blank_end] acetylcholine receptor Nematodes

What anthelmintic may you use for trematodes?

T/F: limited absorption from GIT with an oral anthelmintic is desired

Which of the following are broad spectrum