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Test

MD22 How Medicines Act: Cellular Aspects

Mer Scott 7 preguntas

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Preguntas del test (7)

  1. 1Short-term regulation of cell function is achieved by components which regulate or are regulated by free cytosolic Ca++. This includes:
    1. Ion [blank_start]channels/transporters[blank_end]
    2. Storage and release by [blank_start]organelles[blank_end]
    3. Ca++ dependent regulation of [blank_start]vesicle proteins[blank_end]
    1. Achannels/transporters
    2. Borganelles
    3. Cvesicle proteins
  2. 2Free Ca++ concentration is 10^-7M. Ca++ in tissue fluid is 24mM. Therefore the gradient favours Ca++ exit.
    1. AVerdadero
    2. BFalso
  3. 3Ca2+ entry mechanisms:
    1. Voltage gated Ca2+ channels
    • Allow Ca2+ entry when cell is [blank_start]depolarized[blank_end]
    2. Ligand gated channels
    • Non [blank_start]selective[blank_end]
    3. SOCs (Transient Receptor Potential channel family)
    • Open when ER stores are [blank_start]depleted[blank_end]
    1. Adepolarized
    2. Bselective
    3. Cdepleted
  4. 4Energy for Ca++ extrusion comes from electrochemical gradient for Na+ and this gradient is maintained by Na+/K+ATPase.
    1. AVerdadero
    2. BFalso
  5. 5What are the 2 types of channels in the ER and SR that control release from calcium stores?
    1. AInositol triphosphate receptor (IP3R), Ryanodine receptors (Ca++-induced Ca++ release)
    2. BRyanodine receptors (Ca++-induced Ca++ release), GPCRs
    3. CInositol triphosphate receptor (IP3R), Ionotropic Ca++ receptors
  6. 6Example: calcium channel blockers e.g. verapamil, diltiazem
    • L-type ([blank_start]slow[blank_end]) Ca2+ channel blockers
    • Slow AP [blank_start]conduction[blank_end] in AV [blank_start]node[blank_end]
    • Shorten phase 2 (plateau)
    • Reduce [blank_start]contractility[blank_end]
    • Tx of [blank_start]arrythmias[blank_end]
    1. Aslow
    2. Bconduction
    3. Cnode
    4. Dcontractility
    5. Earrythmias
  7. 7Botulinum toxin selectively binds to cholinergic terminals, cleaves SNARE proteins, and inhibits ACh release.
    1. AVerdadero
    2. BFalso

Información

Descripción
(Medicines) PHCY211 Test sobre MD22 How Medicines Act: Cellular Aspects, creado por Mer Scott el 23/05/2018.
Idioma
English
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