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MD22 How Medicines Act: Cellular Aspects

Mer Scott 7 questions

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Questions in this quiz (7)

  1. 1Short-term regulation of cell function is achieved by components which regulate or are regulated by free cytosolic Ca++. This includes:
    1. Ion [blank_start]channels/transporters[blank_end]
    2. Storage and release by [blank_start]organelles[blank_end]
    3. Ca++ dependent regulation of [blank_start]vesicle proteins[blank_end]
    1. Achannels/transporters
    2. Borganelles
    3. Cvesicle proteins
  2. 2Free Ca++ concentration is 10^-7M. Ca++ in tissue fluid is 24mM. Therefore the gradient favours Ca++ exit.
    1. ATrue
    2. BFalse
  3. 3Ca2+ entry mechanisms:
    1. Voltage gated Ca2+ channels
    • Allow Ca2+ entry when cell is [blank_start]depolarized[blank_end]
    2. Ligand gated channels
    • Non [blank_start]selective[blank_end]
    3. SOCs (Transient Receptor Potential channel family)
    • Open when ER stores are [blank_start]depleted[blank_end]
    1. Adepolarized
    2. Bselective
    3. Cdepleted
  4. 4Energy for Ca++ extrusion comes from electrochemical gradient for Na+ and this gradient is maintained by Na+/K+ATPase.
    1. ATrue
    2. BFalse
  5. 5What are the 2 types of channels in the ER and SR that control release from calcium stores?
    1. AInositol triphosphate receptor (IP3R), Ryanodine receptors (Ca++-induced Ca++ release)
    2. BRyanodine receptors (Ca++-induced Ca++ release), GPCRs
    3. CInositol triphosphate receptor (IP3R), Ionotropic Ca++ receptors
  6. 6Example: calcium channel blockers e.g. verapamil, diltiazem
    • L-type ([blank_start]slow[blank_end]) Ca2+ channel blockers
    • Slow AP [blank_start]conduction[blank_end] in AV [blank_start]node[blank_end]
    • Shorten phase 2 (plateau)
    • Reduce [blank_start]contractility[blank_end]
    • Tx of [blank_start]arrythmias[blank_end]
    1. Aslow
    2. Bconduction
    3. Cnode
    4. Dcontractility
    5. Earrythmias
  7. 7Botulinum toxin selectively binds to cholinergic terminals, cleaves SNARE proteins, and inhibits ACh release.
    1. ATrue
    2. BFalse

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Description
PHCY211 (Medicines) Quiz on MD22 How Medicines Act: Cellular Aspects, created by Mer Scott on 23/05/2018.
Author
Mer Scott
Language
English
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