Test
Module 1 Set A
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Preguntas del test (100)
1Which of the following is/are true regarding phase 1 drug metabolism?
- AAlso known as conjugation reaction
- BIncludes only oxidation
- CGenerally tends to provide a functional group or “handle” to the molecule
- DNOTA
2Which of the following is/are true regarding phase II drug metabolism?
- AAllows the attachment of small, polar and ionizable endogenous compounds
- BAllows the termination or attenuation of a biologic activity
- Cserves to protect the body against chemically reactive compounds or metabolites
- DNOTA
3Which of the following undergo an oxidative reaction?
- AOlefins
- Balcohols, aldehydes
- Caromatic moieties
- Dnitro and azo compounds
4Which of the following is/are examples of drugs that are extensively metabolized by the first pass effect?
- ALidocaine
- BNitroglycerin
- CMorphine
- Dmeperidine
5Glucuronidation is the most common conjugative pathway in drug metabolism. Which of the following is/are responsible for this?
- Areadily available supply of D-glucuronic acid
- Bnumerous functional groups that can combine enzymatically with glucuronic acid
- Cutilization of D-glucuronic acid to conjugate steroids, heparin, chondroitin, catecholamines and thyroxine
- DAOTA
6Which of the following is/are factors affecting drug metabolism?
- AAge
- Beconomic status
- Cspecies and strain
- Dgender
7Which of the following is/are true regarding methylation?
- Agenerally leads to polar or water-soluble metabolites
- Bimportant in the biosynthesis of many endogenous compounds like epinephrine and melatonin
- Cconstitutes only a minor pathway for conjugating drugs or xenobiotics
- DNOTA
8Which of the following is/are considered slow acetylators?
- Aeskimos
- Begyptians
- Cfilipinos
- Djews
9Which of the following may induce metabolism of other drugs?
- Aphenytoin
- Bcimetidine
- Cmeprobamate
- Drifampicin
10The term that denotes the selective metabolism of two or more similar functional groups or two or more similar atoms that are positioned in different regions of a molecule.
- Astereoisomerism
- Bregioselectivity
- Cselective toxicity
- Dsubstrate stereoselectivity
11The process involved in the biotransformation of amitriptyline to nortriptyline.
- AN-demethylation
- BAromatic hydroxylation
- CEpoxidation
- DEster hydrolysis
12The biotransformation of chloral hydrate via aldehyde reduction forms?
- Adesipramine
- Bmesoridazine
- Ctrichloroethanol
- Dsulindac
13What process is involved in the biotransformation of prednisone to prednisolone?
- Aketone reduction
- BO-demethylation
- Csulfoxide reduction
- DAromatic hydroxylation
14What process is involved in the biotransformation of phenylbutazone to oxybutazone?
- Aaromatic hydroxylation
- Bketone reduction
- CN-acetylation
- DS-oxidation
15Which of the following is/are metabolites?
- A6-mercaptopurine
- Bphenylbutazone
- Cprednisolone
- Dacetaminophen
16Which of the following is/are parent drug/s?
- Adigitoxin
- Bhydrocortisone
- Cprimidone
- Dpropranolol
17The property of chemicals to destroy one form of life without harming another.
- Astereoisomerism
- Bregioselectivity
- Cselective toxicity
- Dsubstrate stereoselectivity
18Which of the following may be used to classify chemotherapeutic agents?
- Achemical type
- Bbiologic properties
- Ctherapeutic indications
- DNOTA
19Which of the following is/are characteristics of an ideal antiseptic?
- Arapid and sustained lethal action against microorganisms
- Bretain activity in the presence of body fluids
- Chigh surface tension
- DNOTA
20An agent that prevents infection by the destruction of pathogenic microorganisms when applied to inanimate objects.
- AAntiseptic
- Bdisinfectant
- Cantibiotic
- Dsanitizer
21Generally accepted other names of alcohol USP
- AEthanol
- Bwood alcohol
- Cspiritus vini rectificatus
- Dwine spirit
22Ethanol that has been rendered unfit for use in intoxicating beverages by the addition of other substances.
- ADenatured alcohol
- Bwood alcohol
- Cisopropyl alcohol
- Dformaldehyde
23Phenol coefficient is defined as the ratio of a disinfectant to the dilution of phenol required to kill a given strain of a bacterium. What microorganism is used in determining the phenol coefficient?
- ABacillus subtilis
- BEnterobacter aerogenes
- CPseudomonas aeruginosa
- DSalmonella typhi
24A 2% solution of iodine in 50% alcohol with sodium iodide.
- AIodine solution
- Biodine tincture
- Clugol’s solution
- Dmayer’s reagent
25A preparation of 5% Iodine in water with potassium iodide?
- AIodine solution
- Biodine tincture
- Clugol’s solution
- Dmayer’s reagent
26A preparation of 2% iodine in water with sodium iodide?
- AIodine solution
- Biodine tincture
- Clugol’s solution
- Dmayer’s reagent
27Povidone-Iodine
- AWater-soluble complex that releases iodine slowly
- Bprovides a non-toxic, non-irritating,non-volatile and non-staining form of iodine
- Cused as an antiseptic for skin application before surgery and injection
- DNOTA
28A dye available as vaginal suppositories for the treatment of yeast infections.
- AMalachite green
- Bmethylene blue
- Cphenolphthalein
- Dgentian violet
29Dye used as an antidote for cyanide poisoning?
- AMalachite green
- Bmethylene blue
- Cphenolphthalein
- Dgentian violet
30A potent antifungal substance with a polyene structure from Streptomyces nodosus
- ANystatin
- Bgriseofulvin
- Cnatamycin
- Damphotericin B
31The aglycone portion of nystatin consisting of a 38-membered ketone ring with a single tetracene and diene chromophores isolated from each other by a methylene group, one carboxyl, one keto, and eight hydroxyl groups.
- AMykinac
- Bmycostatin
- Cnystatinolide
- Dcandeptin
32Polyene antibiotic first isolated in 1951 from a strain of Streptomyces noursei by hanzen and brown.
- ANystatin
- Bamphotericin b
- Cnatamycin
- Dgriseofulvin
33Griseofulvin
- ARecommended for the systemic treatment of refractory ringworm infections
- Bits bioavailability is notoriously poor
- Cit is supplied in “microsize” and “ultramicrosize” forms
- DNOTA
34A series of synthetic antibacterial agents patterned after nalidixic acid, with an effective antibacterial spectrum largely confined to gram-negative bacteria.
- Aquinolones
- Bdihydrotriazines
- Cbiguanides
- Dpolyenes
35The structure found among the quinolones which is essential for their antibacterial activity is 1,4-dihydro-4-oxo-3-pyridine carboylic acid.
- ATrue
- BFalse
36Its congeners represent important alternatives for the treatment of urinary tract infections caused by strains of Proteus resistant to other agents.
- ANorfloxacin
- Bcinoxacin
- Cnitrofurantoin
- Dnalidixic acid
37Antibiotic
- AA synthetic product produced as a structural analogue of a naturally occurring antibiotic
- Bit antagonizes the growth or the survival of one or more species of microorganisms
- Cit is effective in low concentration
- DNOTA
38One who led the isolation of streptomycin from Streptomyces griseus:
- APasteur & Joubert
- Bwaksman
- CVuillemin
- DFlorey and Chain
39Antibiotic that binds with ribosome 30s subunit
- AChloramphenicol
- Btetracycline
- Cerythromycin
- Dlincomycins
40Benzylpenicillin binds preferentially to:
- APBP 1a & 1b
- BPBP 2
- CPBP 3
- DPBP 6
41Methicillin is chemically called as:
- A2-ethoxy-1-napthylpenicillin
- B5-methyl-3-phenyl-4-isoxazolyl penicillin
- C5-methyl-3-(2,6-dichlorophenyl)-4-isoxazolyl-penicillin
- D2,6-dimethoxyphenyl penicillin
42Amoxicillin
- AD-?-Amino-p-hydroxybenzyl-penicillin
- B?-Carboxy-3-thienyl penicillin
- C?-(1-methanesulfonyl-amino) benzylpenicillin
- DD-?-aminobenzyl penicillin
43Structure of the penicillin molecule shows it to contain a fused ring system which is the:
- A?-lactam thiazolidine
- B?-lactam penam
- C6-aminopenicillanic acid
- D?-lactam phenyl penicillin ring
44Members of the 4-isoxazolyl penicillin family require these substituents for effectiveness against ?-lactamase producing Staphylococcus aureus.
- A3-aryl & 5-methyl group
- B3-acyl & 6-methyl group
- C3-phenyl & 2-methoxy group
- D3-phenyl & 2-methyl group
45These are major antigenic determinants that are formed when penicillins or its rearrangement products in vivo react with lysine-e-amino groups of proteins resulting to allergic reactions.
- APenicillenic acids
- Bpenicilloyl proteins
- Cpenicillanic proteins
- Dpenicillanic acids
46This is prepared by the reaction of ampicillin with acetone
- AUnipen
- Bhetacillin
- Cunasyn
- Dmethicillin
47Class 1 ?-lactamase inhibitors have hetero atom leaving at position 1. Which of these is/are Class II inhibitors:
I. Carbapenems
II. Sulbactam
III. Clavulanic Acid- AI only
- BI, II
- CII, III
- DIII only
48Augmentin is a combination of:
- AK salt of Clavulanic Acid
- Bamoxicillin
- Campicillin
- Dsulbactam
49Unasyn is a fixed-dose combination of:
- AAmoxicillin
- Bsulbactam
- Campicillin
- Dclavulanic
50Primaxin is a combination of:
- ATazocillin
- Bimipenem
- Cpiperacillin
- Dcilastatin
51Imipenem is the most successful of a series of chemically stable derivatives of thienamycin in which the primary amino group is converted to a non-nucleophilic basic function. Imipenem is also:
- A5-acetamido thienamycin
- B5-methyl-3-phenyl-4-isoxazolyl penicillin
- Cn-formimidoyl thienamycin
- D?-imidazolyl ethylamine
52D-(4-amino-4-carboxybutyl) is:
- APenicillin N
- Bsynnematin B
- Ccephalosporin N
- Dchloramphenicol B
53Cephalosporin C contains:
- APenicillanic acid
- Bthiazolidine ring
- Clactone ring
- Ddihydrothiazine ring
54A parenteral cephamycin
- ACefoxitin
- Bceftazidime
- Ccephalexin
- Dcefadroxil
55Zinacef is the first of a series of a-methoxyimino-acyl-substituted cephalosporins that constitute most of the third generation agents. Zinacef is:
- ASterile cefotaxime Sodium, USP
- BCefuroxime Sodium, USP
- CMoxalactam Disodium, USP
- DCefepime, USP
56The factors that contribute to an extremely long serum half-life of sterile ceftriaxone disodium, USP
- AHigh fraction of protein binding in the plasma
- Bslow urinary excretion
- Cit is not metabolized in vivo
- DNOTA
57This increases stability to ?-lactamases while increasing activity against G(-) bacteria at the same time in monobactams:
- A4-methyl group
- B3-methoxy group
- Coximinoacyl group
- D2-aryl group
58The 1st aminoglycoside antibiotic to be used in chemotherapy:
- AAmikacin
- Bgentamicin
- Cstreptomycin
- Dkanamycin
59MOA of Aminoglycosides:
- AInterferes with cell wall synthesis
- Bact directly on the bacterial ribosome to inhibit the initiation of protein synthesis
- Cinterferes with the fidelity of translation of the genetic message
- DNOTA
60Extrachromosomals which are self-replicative and transferable by conjugation that is responsible for the transfer of resistance from one bacterium to another.
- AR-factor
- BF-factor
- CS-factor
- DX-factor
61SAR of Aminoglycosides: important for characteristic broad-spectrum antibacterial activity & is the primary target for bacterial inactivating enzymes.
- ARing I
- BRing II
- CRing III
- DRing IV
62Known as Streptomycin B
- AStreptomycin
- BMannisidostreptomycin
- CHydroxystreptomycin
- DParomomycin Sulfate, USP
63Acid hydrolysis of Streptomycin yields:
- AStreptidine
- BStreptobiosamine
- CDeoxystreptamine
- DNOTA
64Neomycin is obtained from:
- AS. fradiae
- BS. rimosus
- CS. kanamyceticus
- DMicromonospora purpurea
65The synthesis of this semisynthetic aminoglycoside involves simple acylation of the 1-amino group of the deoxystreptamine ring of Kanamycin A with L-amino-a-hydroxybutyric acid (L-AHBA)
- ATobramycin
- BNetilmicin
- CAmikacin
- DGentamicin
66A group of antibiotics that are derivatives of an octahydronaphthalene, a hydrocarbon system that comprises four annelated six-membered rings.
- AMacrolides
- Btetracycline
- Clincomycins
- Dsulfonamides
677-Chloro-6-demethyl tetracycline is:
- Ademeclocycline
- BOxytetracycline
- Cminocycline
- DDoxycycline
68Macrolide antibiotics have these common characteristics:
- ALarge lactone ring
- Bketone group
- Ca glycosidically linked amino sugar
- Dan asymmetric carbon atoms in the acylamidopropanediol chain
69Bacillus subtilis strain that was isolated from debrided tissue of a compound fracture in 7-year old Margaret Tracy produced this antibiotic.
- AGramicidin
- BBacitracin
- CColistin
- DPolymyxin
70The first of the widely used broad-spectrum antibiotic that was isolated by Ehrlich in 1947 from S. venezuelae
- AClindamycin
- BChloramphenicol
- CVancomycin
- DNovobiocin
71Erythromycin B differs from Erythromycin A only at carbon 12, at which hydroxyl group is replaced by ______, which renders it more acid stable.
- ABromine
- BChlorine
- CHydrogen
- DOxygen
72These are sulfur-containing antibiotics isolated from S. lincolnensis
- ABacitracin
- Bnovobiocin
- Clincomycins
- Dvancomycins
737-Chloro-7-deoxy lincomycin
- ACleocin
- BUnasyn
- CUnipen
- DLincocin
74Bacitracin’s bactericidal effect through an inhibition of mucopeptide cell wall synthesis is enhanced by:
- AP
- BZn
- CCl
- DS
75Analogue of podophyllotoxin that is an inhibitor of Topoisomerase II which contains methyl as its R group:
- AVindoline
- BEtoposide
- CVincristine
- DEpipodophyllotoxin
76The complex structures in vinca alkaloid composed of indole-containing moiety and an indoline-containing moiety:
- AIndoline
- BVindoline
- CVindesine
- DCatharanthine
77Is an antineoplastic agent preparation from E. coli containing the enzyme L-asparagine amidohydrolase
- AAsparaginase
- BElspar
- CPipobroman
- DPlatinol
78An antineoplastic drug active against rapidly proliferating cells in the synthesis phase during which it prevents the formation of deoxyribonucleotides by inhibition of ribonucleotide diphosphate reductase.
- ACarboplatin
- Bhydroxyurea
- Cmitoguazone
- Dhycanthone
79Used primarily for polycythemia vera:
- AHexamethylamine
- Basparaginase
- Ctamoxifen
- Dpipobroman
80D-Homo-17a-oxa androsta-1,4-dione prepared by microbial transformation of progesterone
- ATamoxifen
- Btestolactone
- Cmegestrol
- Dethinyl estradiol
81Interferons are secreted by cells in response to viral infections or other chemical or biologic inducers. The major classes of interferons are:
- Aalpha
- BBeta
- CLambda
- DGamma
82It is a highly purified protein containing 165 amino acids manufactured from a strain of E.coli bearing a genetically engineered plasmid containing an interferon alfa-2a gene from human leukocytes.
- ARIFN
- BIFLrA
- CRoferon-A
- DInteron
83This is absolutely essential for the in-vitro carbonic anhydrase inhibitory activity and for the production of a diuresis in vivo.
- ASulfamoyl group
- Bneptazane
- Camino group
- DImino group
84Diamox
- AAcetazolamide
- BHydrochlorothiazide
- CAmoxicillin
- DDichlorphenamide
85Benzothiazine-1,1-dioxide nucleus is contained in:
- ACarbonic anhydrase inhibitors
- Bthiazide diuretics
- Cloop diuretics
- Dphenoxyacetic acids
864-Chloro-N-furfuryl-5-sulfamoyl anthranilic acid is:
- ABumetanide
- Bfurosemide
- Cethacrynic acid
- Dchlorothiazide
87Primary compound selected from a host of pteridine analogues and resembles the structure of folic acid and certain dihydrofolate reductase inhibitors.
- ASpironolactone
- Bamiloride
- Ctheophylline
- Dtriamterene
88A pyrazinoyl guanidine diuretic that inhibits the electrogenic entry of 2% to 3% of the filtered load of Na into the tubule cells.
- ATriamterene
- Bspironolactone
- Camiloride
- Daldosterone
89The major adverse effect of midamor:
- Ahypomagnesemia
- Bhyponatremia
- Chypocalcemia
- Dhyperkalemia
90?-imidazolylethylamine, an autacoid, is widespread in nature being found in ergot and other plants and in all organs and tissues of the human body. It’s also known as:
- A1H-imidazole-4-ethenamine
- Bhistamine
- Cserotonin
- DNOTA
91The major source of histamine in the body results from the decarboxylation of this amino acid:
- ATryptophan
- BHistidine
- CTyrosine
- DPhenylalanine
92Drowsiness is a side effect of antihistamines that is most common to the:
- AEthylenediamines
- Btertiary aminoalkyl ethers
- Cphenothiazines
- Dcimetidine
93A propylamine derivative:
- ADiphenhydramine
- BClemastine
- CCarbinoxamine
- DBrompheniramine
94Dramamine
- ADoxylamine
- BDimenhydrinate
- CDiphenhydramine
- DCyclizine
95The piperazine, imidazoline and phenothiazine type antihistamines contain the following moiety:
- AAminoalkyl ethers
- Bethylene diamine
- Cpropylamine
- Dbutyrophenone
96Antihistamine resulting from the chlorination of pheniramine in the para position of the phenyl ring that gives a tenfold increase in potency with no appreciable changes in toxicity.
- ABrompheniramine
- Bchlorpheniramine
- Cpyrrobutamine
- Dpromethazine
97A sulfone derivative investigated initially to be the most effective drug for the treatment of leprosy and has useful antimalarial property but was too toxic.
- A4,4’-diamidodiphenylsulfide
- B4,4’-diaminodiphenylsulfone
- C3,4’-diaminediphenylsulfide
- D3,4’-diamidodiphenylsulfone
98What antibiotic caused a major advance in the treatment of tuberculosis?
- AIsoniazid
- Bethionamide
- Crifampin
- Dcycloserine
99Ethambutol is remarkably stereospecific. Toxicities of its isomers are about equal but their activity varies considerably. Factors that have pronounced effect on the activity are:
- ALength of the alkylene chain
- Bnature of the branching with the alkyl substituents in the nitrogens
- Cextent of N-alkylation
- Dpyranolone ring at the C4 of the compound
100Ethionamide is a second-line treatment drug for tuberculosis and used in the treatment of INH-resistant tuberculosis or when the patient is intolerant to INH and other drugs. What is its structural difference with the INH series?
- A5 - substitution
- B2 - substitution
- Caddition of a thiazolidine ring
- Daddition of a pyranolone ring
Información
- Descripción
- Medicine Test sobre Module 1 Set A, creado por Bryan Suringa el 06/11/2020.
- Autor
- Bryan Suringa
- Idioma
- English
- Visitas
- 134
- Etiquetas
- Valoración
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