Metoprolol pharmacokinetics

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Flashcards on Metoprolol pharmacokinetics, created by Em J on 10/06/2018.
Em J
Flashcards by Em J, updated more than 1 year ago
Em J
Created by Em J over 6 years ago
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Resource summary

Question Answer
The steps in pharmacokinetics DADME Dissolution Absorption Distribution Metabolism Excretion
Dissolution Easily dissolved in the stomach and GIT
Absorption Quickly and readily absorbed by the GIT into circulation
Distribution Quickly distributed across the body (3 - 6 hour half-life) Can cross the blood-brain barrier, and cross the placenta as well as enter breast milk.
Metabolism Has a 50% oral bioavailability due to the first pass effect - readily metabolised by the liver - into three different metabolites
Excretion Extensively (95%) excreted by the kidneys as metabolites and a small amount of unmetabolised drug
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