16387248
Description
Flashcards by Alice Hathaway, updated more than 1 year ago
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Created by Alice Hathaway
over 5 years ago
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| Question | Answer |
| What is the input for the citric acid cycle? | Acetly-Co A |
| What happens? | Acetate enters the cycle, CoAsh released to be reused |
| What is first formed and how? | Oxaloacetate and acetate combined to form citrate uses citrate synthase |
| What is formed from citrate? | Isocitrate aconitase |
| What is formed from isocitrate? | Alphaketoglutarate (AKA 2-oxoglutarate) NADH formed CO2 released Isocitrate dehydrogenase |
| What is formed from alpha ketoglutarate? | Succinyl CoA CoAsh added CO2 removed NADH produced Oxoglutarate dehydrogenase |
| What is formed from Succinyl Co A? | Succinate GTP produced Succinate thiokinase |
| What is produced from succinate? | Fumerate FADH2 produced Succinate dehydrogenase |
| What is produced from fumerate? | Malate H2O added Fumerase |
| What is produced from malate? | Oxaloacetate NADH produced Malate dehydrogenase |
| Purine Nucleotide Cycle | Oxaloacetate rate-limiting if much acetyl-CoA. Breakdown of ATP in strenuous exercise generates fumerate to produce more oxaloacetate |
| How is citrate synthase controlled? | Allosterically inhibited by ATP |
| Why is citrate synthase regulation important? | Gluconeogenesis. Inhibited by hight [ATP]. Oxaloacetate directed to gluconeogenesis and acetyl-CoA for ketone bodies to fuel brain |
| How is isocitrate dehydrogenase regulated? | Inhibited by ATP and NADH in fed state |
| How is oxoglutarate dehydrogenase controlled? | Inhibited by NADH and succinyl CoA Stimulated by Ca2+ |
| How is Acetyl CoA produced? | Pyruvate dehydrogenase |
| How is pyruvate dehydrogenase controlled | Inhibited by pyruvate Stimulated by Ca2+ - "on" in exercise Regulated by ratio of NADH/NAD+ and acetlycoA/coA |
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