Flashcards
Kreb Cycle aka Citric Acid Cycle aka Tricarboxylic Acid Cycle
Cards in this deck (21)
- 1Where does the Krebs cycle occur?In the mitochondrial matrix.
- 2What are the net products per Acetyl-CoA in the Krebs cycle?3 NADH, 1 FADH₂, 1 GTP, and 2 CO₂.
- 3What are the net products per glucose?6 NADH, 2 FADH₂, 2 GTP, and 4 CO₂
- 4What is the mnemonic for Krebs Cycle intermediates?"Oh Can I Keep Studying Science For Medical School”
(Oxaloacetate, Citrate, Isocitrate, α-Ketoglutarate, Succinyl-CoA, Succinate, Fumarate, Malate) - 5At which steps is NADH produced in the Krebs cycle?Step 3 (Isocitrate Dehydrogenase),
Step 4 (α-Ketoglutarate Dehydrogenase), Step 8 (Malate Dehydrogenase). - 6At which step is FADH₂ produced?Step 6 (Succinate Dehydrogenase).
- 7At which step is GTP (or ATP) produced?Step 5 (Succinyl-CoA Synthetase).
- 8What is the rate-limiting enzyme of the Krebs cycle?Isocitrate Dehydrogenase.
- 9What activates and inhibits Isocitrate Dehydrogenase?Activated by ADP and Ca²⁺; Inhibited by ATP and NADH.
- 10What are the three key regulatory enzymes in the Krebs cycle?Citrate Synthase (Step 1),
Isocitrate Dehydrogenase (Step 3),
α-Ketoglutarate Dehydrogenase (Step 4). - 11Where do NADH and FADH₂ go after the Krebs cycle?They enter the Electron Transport Chain (ETC) to produce ATP.
- 12How much ATP does NADH yield?A: 2.5 ATP per NADH.
- 13How much ATP does FADH₂ yield?1.5 ATP per FADH₂.
- 14How much ATP is generated from the Krebs cycle per glucose?20 ATP total:
• 6 NADH → 15 ATP
• 2 FADH₂ → 3 ATP
• 2 GTP → 2 ATP - 15What is the only enzyme of the Krebs cycle located in the inner mitochondrial membrane?Succinate Dehydrogenase.
- 16What inhibits α-Ketoglutarate Dehydrogenase?ATP, NADH, and Succinyl-CoA.
- 17What activates α-Ketoglutarate Dehydrogenase?Ca²⁺.
- 18What is the mnemonic for Krebs cycle regulation?"ATP and NADH Stop; ADP and Ca²⁺ Go!" (ATP and NADH inhibit; ADP and Ca²⁺ activate.)
- 19How much ATP is generated from one turn of the Krebs cycle?10 ATP per Acetyl-CoA.
- 20How much ATP is generated from the Krebs cycle per glucose?20 ATP per glucose.
- 21What is the mnemonic for the Krebs Cycle enzymes?Cool Aunts In Kansas Sell Special
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(Citrate synthase, Aconitase, Isocitrate dehydrogenase, Alpha Ketoglutarate dehydrogenase, Succinyl CoA synthetase, Succinate dehydrogenase, Fumarase, Malate dehydrogenase)
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- Kreb Cycle aka Citric Acid Cycle aka Tricarboxylic Acid Cycle
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- Ginger Scally
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