Psychosis, Bipolar


Pharmacology for psychosis and bipolar disorder
Eavan Brennan
Flashcards by Eavan Brennan, updated more than 1 year ago
Eavan Brennan
Created by Eavan Brennan over 4 years ago

Resource summary

Question Answer
What are antipsychotic drugs for relief of symptoms of schizophrenia prevent relapse
what are the symptoms of schizophrenia Positive=hallucinations(commonly auditory) thought disorders, delusions, lack of insight Negative=social withdrawal, apathy, low motivation
what is dopamine a neurotransmitter to the brain
how do antipsychotics act blocking dopamine d2 receptors in the brain
what are first generation antipsychotics d2receptor antagonists
second generation? dopamine-serotonin antagonists
Cautions for antipsychotics cardiac, renal, hepatic and CNS impairment drowsiness alcohol=worse s/e response and tolerance differs
examples of first gen antipsychotics chlorpromazine flupentixol haloperidol zuclopenthixol
examples of second gen/atypical risperidone olanzapine clozapine paliperidone quetiapine sertindole
Side effects of antipsychotics CV=tachycardia, arrhythmias, hypotension extra-pyramidal ie parkinsons like tremor, dystonia, akathesia, tardive dyskinesia NBatypical considered to cause fewer extrapyramidal
side effects of both sedation, antimuscarinic, sexual dysfunction, dizziness and postural hypotension, metabolic incl ++ weight gain, hyperglycaemia, ++cholesterol, endocrine
Depot injections like zuclophentixol flupentixol deacoante haloperidol risperidone
what are the purpose of depot injections maintenance when compliance with oral therapy is unreliable
Medication for bipolar and mania Valproic acid - sodium valproate(avoid in childbearing years) lithium - narrow therapeutic window
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