Created by Eavan Brennan
almost 5 years ago
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Question | Answer |
What are antipsychotic drugs for | relief of symptoms of schizophrenia prevent relapse |
what are the symptoms of schizophrenia | Positive=hallucinations(commonly auditory) thought disorders, delusions, lack of insight Negative=social withdrawal, apathy, low motivation |
what is dopamine | a neurotransmitter to the brain |
how do antipsychotics act | blocking dopamine d2 receptors in the brain |
what are first generation antipsychotics | d2receptor antagonists |
second generation? | dopamine-serotonin antagonists |
Cautions for antipsychotics | cardiac, renal, hepatic and CNS impairment drowsiness alcohol=worse s/e response and tolerance differs |
examples of first gen antipsychotics | chlorpromazine flupentixol haloperidol zuclopenthixol |
examples of second gen/atypical | risperidone olanzapine clozapine paliperidone quetiapine sertindole |
Side effects of antipsychotics | CV=tachycardia, arrhythmias, hypotension extra-pyramidal ie parkinsons like tremor, dystonia, akathesia, tardive dyskinesia NBatypical considered to cause fewer extrapyramidal |
side effects of both | sedation, antimuscarinic, sexual dysfunction, dizziness and postural hypotension, metabolic incl ++ weight gain, hyperglycaemia, ++cholesterol, endocrine |
Depot injections like | zuclophentixol flupentixol deacoante haloperidol risperidone |
what are the purpose of depot injections | maintenance when compliance with oral therapy is unreliable |
Medication for bipolar and mania | Valproic acid - sodium valproate(avoid in childbearing years) lithium - narrow therapeutic window |
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