20378882
Description
Flashcards by Eavan Brennan, updated more than 1 year ago
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Created by Eavan Brennan
almost 5 years ago
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| Question | Answer |
| What are antipsychotic drugs for | relief of symptoms of schizophrenia prevent relapse |
| what are the symptoms of schizophrenia | Positive=hallucinations(commonly auditory) thought disorders, delusions, lack of insight Negative=social withdrawal, apathy, low motivation |
| what is dopamine | a neurotransmitter to the brain |
| how do antipsychotics act | blocking dopamine d2 receptors in the brain |
| what are first generation antipsychotics | d2receptor antagonists |
| second generation? | dopamine-serotonin antagonists |
| Cautions for antipsychotics | cardiac, renal, hepatic and CNS impairment drowsiness alcohol=worse s/e response and tolerance differs |
| examples of first gen antipsychotics | chlorpromazine flupentixol haloperidol zuclopenthixol |
| examples of second gen/atypical | risperidone olanzapine clozapine paliperidone quetiapine sertindole |
| Side effects of antipsychotics | CV=tachycardia, arrhythmias, hypotension extra-pyramidal ie parkinsons like tremor, dystonia, akathesia, tardive dyskinesia NBatypical considered to cause fewer extrapyramidal |
| side effects of both | sedation, antimuscarinic, sexual dysfunction, dizziness and postural hypotension, metabolic incl ++ weight gain, hyperglycaemia, ++cholesterol, endocrine |
| Depot injections like | zuclophentixol flupentixol deacoante haloperidol risperidone |
| what are the purpose of depot injections | maintenance when compliance with oral therapy is unreliable |
| Medication for bipolar and mania | Valproic acid - sodium valproate(avoid in childbearing years) lithium - narrow therapeutic window |
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