2638935
Description
Flashcards by Alexandria Lau, updated more than 1 year ago
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Created by Alexandria Lau
almost 9 years ago
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| Question | Answer |
| Which two key features does Ach have? | 1. Ester linkage for degradation 2. Quarternary amine for permanent positive charge |
| Which 3 ways are used to remove Ach from a sypnase? | 1. Presynaptic reuptake 2. Acetylcholinerase (AchE) break down 3. Simple diffusion to surrounding |
| What is the synthesis process of Ach? | |
| What are the 2 types of Ach receptors and what kind of receptors are they? | 1. Nicotinic Ach receptor; coupled to Na+ channel (Fast) 2. Muscarinic Ach receptor; coupled to G-protein (slow) |
| Where is the two types of Ach receptors distributed in the human body? | nAchR: Neoromuscular junction, CNS, autonomic ganglia mAchR: CNS, full parasympathetic NS, preganglionic of sympathetic NS |
| What is the structure of noradrenaline and adrenaline respectively? | |
| How is noadrenaline removed form a synapse? | Main: Presynaptic reuptake Later: Catechol-O-Methyltransferase (COMT) |
| What is the biosynthesis pathway of norepinephrine and epinephrine? | |
| What is the potency of different agonist on the subtypes of adrenoceptors? | alpha: NA>Ad>Isoprenaline beta: Isoprenaline>Ad>NA |
| What is the anatomical organization of adrenergic nervous transmission? | |
| Which nerve branches innervate sympathetic and parasympathetic nervous system respectively? | Sympathetic: Ganglia located close to spinal cord @thorax branches Parasympathetic: Ganglia close to target organ @sacral and medullary branches |
| What is the pathway for innervating the adrenal medulla and what are it's responses? | |
| Which nerve is involved in slowing the heart rate? Which receptor is involved and which drug can block it? | Vagus nerve innervate SA/AV node and atrial myocardium. Muscarinic AchR. Blocked by atropine. |
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