Flashcards
Lecture 8: Cholinergic and Adrenergic Transmission
Cards in this deck (13)
- 1Which two key features does Ach have?1. Ester linkage for degradation
2. Quarternary amine for permanent positive charge - 2Which 3 ways are used to remove Ach from a sypnase?1. Presynaptic reuptake
2. Acetylcholinerase (AchE) break down
3. Simple diffusion to surrounding - 3What is the synthesis process of Ach?
- 4What are the 2 types of Ach receptors and what kind of receptors are they?1. Nicotinic Ach receptor; coupled to Na+ channel (Fast)
2. Muscarinic Ach receptor; coupled to G-protein (slow) - 5Where is the two types of Ach receptors distributed in the human body?nAchR: Neoromuscular junction, CNS, autonomic ganglia
mAchR: CNS, full parasympathetic NS, preganglionic of sympathetic NS - 6What is the structure of noradrenaline and adrenaline respectively?
- 7How is noadrenaline removed form a synapse?Main: Presynaptic reuptake
Later: Catechol-O-Methyltransferase (COMT) - 8What is the biosynthesis pathway of norepinephrine and epinephrine?
- 9What is the potency of different agonist on the subtypes of adrenoceptors?alpha: NA>Ad>Isoprenaline
beta: Isoprenaline>Ad>NA - 10What is the anatomical organization of adrenergic nervous transmission?
- 11Which nerve branches innervate sympathetic and parasympathetic nervous system respectively?Sympathetic: Ganglia located close to spinal cord @thorax branches
Parasympathetic: Ganglia close to target organ @sacral and medullary branches - 12What is the pathway for innervating the adrenal medulla and what are it's responses?
- 13Which nerve is involved in slowing the heart rate? Which receptor is involved and which drug can block it?Vagus nerve innervate SA/AV node and atrial myocardium.
Muscarinic AchR.
Blocked by atropine.
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- Pharm (Autonomic Nervous System) Flashcards on Lecture 8: Cholinergic and Adrenergic Transmission, created by Alexandria Lau on 02/05/2015.
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- Alexandria Lau
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