Lecture 8: Cholinergic and Adrenergic Transmission

Alexandria Lau
Flashcards by Alexandria Lau, updated more than 1 year ago
Alexandria Lau
Created by Alexandria Lau almost 6 years ago
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Pharm (Autonomic Nervous System) Flashcards on Lecture 8: Cholinergic and Adrenergic Transmission, created by Alexandria Lau on 05/02/2015.

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Question Answer
Which two key features does Ach have? 1. Ester linkage for degradation 2. Quarternary amine for permanent positive charge
Which 3 ways are used to remove Ach from a sypnase? 1. Presynaptic reuptake 2. Acetylcholinerase (AchE) break down 3. Simple diffusion to surrounding
What is the synthesis process of Ach?
What are the 2 types of Ach receptors and what kind of receptors are they? 1. Nicotinic Ach receptor; coupled to Na+ channel (Fast) 2. Muscarinic Ach receptor; coupled to G-protein (slow)
Where is the two types of Ach receptors distributed in the human body? nAchR: Neoromuscular junction, CNS, autonomic ganglia mAchR: CNS, full parasympathetic NS, preganglionic of sympathetic NS
What is the structure of noradrenaline and adrenaline respectively?
How is noadrenaline removed form a synapse? Main: Presynaptic reuptake Later: Catechol-O-Methyltransferase (COMT)
What is the biosynthesis pathway of norepinephrine and epinephrine?
What is the potency of different agonist on the subtypes of adrenoceptors? alpha: NA>Ad>Isoprenaline beta: Isoprenaline>Ad>NA
What is the anatomical organization of adrenergic nervous transmission?
Which nerve branches innervate sympathetic and parasympathetic nervous system respectively? Sympathetic: Ganglia located close to spinal cord @thorax branches Parasympathetic: Ganglia close to target organ @sacral and medullary branches
What is the pathway for innervating the adrenal medulla and what are it's responses?
Which nerve is involved in slowing the heart rate? Which receptor is involved and which drug can block it? Vagus nerve innervate SA/AV node and atrial myocardium. Muscarinic AchR. Blocked by atropine.
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