434841
Description
Flashcards by Sammy Crockett, updated more than 1 year ago
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Created by Sammy Crockett
over 10 years ago
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| Question | Answer |
| Biochemistry | FAs are carboxylic acids Lower blood pH More FA at liver, more triacyglycerol FA to mitochndria to oxidise (when low glucose) Glucagon promotes uptake of FA Malonyl CoA switches off transport into mitochondria FAs committed to storage Increase of acids=Uncontrolled beta oxidation=uncontrolled keto acid production |
| Levels | GLUT saturates at up to 10-12mmol/L Free FA from 0.2-1.0mM to 3-4mM Ketone body from 0.2mM to 10-20mM Blood pH from 7.4 to 7.1 |
| Response to acidosis | Carbonic anhydrase reaction shifts H+ + HCO3- -> H2CO3 to H2CO3 -> CO2 + H2O Respiratory compensation Kussmaul breathing Excretion of volatile excess acetone in breath |
| Dehydration | Decreased GFR (glomerular filtration rate) Pre-renal uraemia (indicates not kidney prob) Increased urea and creatinine Decreased ECF Less fluid through kidneys Decreased rate Urea can also be from increased deamination in liver |
| Acidosis -> Hyperkalaemia | Lack of insulin Increase in H+ in ECF H+ can move back in but must swap with K+ K+ increases in plasma=hyperkalaemia K+ maintains cardiac rhythmicity, so increase can result in sudden cardiac death |
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