48336
Description
Flashcards by Bhavi Mistry, updated more than 1 year ago
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Created by Bhavi Mistry
about 11 years ago
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| Question | Answer |
| Thiopentone | Short acting barbituate anaesthetic (positive GABAa allosteric modulation at the B subunit) |
| Why is thiopentone replaced by propofol? | Repeated dose of thiopentane saturates tissue stores, so it sits around in the blood, and can therefore not maintain a constant infusion |
| Propofol | Rapid metabolism and non-accumulative (no storage in fat/muscle) |
| tiletamine (phencyclidine) | NMDA channel - |
| midazolam | Benzodiazepine amnesia used in endoscopy when full analgesia is not needed |
| Advantages of injectable anaesthetics | High therapeutic index No CV/Resp depression Non-cumulative Analgesic |
| Disadvantages of injectable anaesthetics | Psychic disturbance Involuntary movement |
| Halothane | Toxic metabolite (inhalation anaesthetics) |
| Enflurane | Convulsions |
| Des/Sevoflurane | Rapid induction |
| Advantages of inhalation anaesthetics | Maintenance of stage III (surgical anaesthaesia) Small lipid soluble molecules cross the alveolar membrane easily |
| Disadvantages of inhalation anaesthetics | Problem if lungs are damaged Toxicity is associated with their metabolism |
| Review | Stages of anaesthaesia Effects on the CNS Effects on other channels |
| Unitary theory | No obvious structure-activity relationship |
| Lipid theory | Membrane expansion leads to disruption of function |
| Meyer+overton | The potency of a drug is proportional to its lipid solubility |
| Protein theory | Binding to hydrophobic regions (true, but not always in the same way) |
| Etomidate | Enhancement of GABAaR function |
| Volatile anaesthetics | Bind between alpha and beta subunits |
| IV anaesthetics | Bind to beta subunits |
| N2O | (-) NMDA Rs |
| Xenon | (-)NMDA Rs |
| Ketamine | (-) NMDA R |
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