Cognitive enhancement

Question	Answer
Clonidine	Alpha 2 antagonist Treatment of impulsivity
Orlistat	lipase inhibitor Peripheral treatment of obesity
Lorcaserin	Selective 5HT2C antagonist decrease of food intake
Rimonanabant	Selective CBIR blocker Control of addiction/feeding
Fenfluramine	SSRI Decreasing addiction
Phentermine	Sympathomimetic Decreases feeding
Hormonal control of feeding	NPY (leptin) Melanocrotin Galantin Insulin
Beta 3 adrenoceptor	Increases thermogenesis Peripheral regulation of food intake
Monoamines	5HT and NA Peripheral regulation of food intake
5HT 2C Rs	Decrease food intake Central control of food intake
alpha 2 receptors	Increase food intake Central regulation of food control
Diseases of hypodopaminergic function	Cocaine addiction Alcoholism Obesity
Addiction	Correlation between low D2R numbers and addiction (+ liking the drug) Loss of control pathways - disruption of balance and ability to make rational decisions
Desipramine	NA TCA Impulsivity treatment
NA	Locus coeruleus Vigilance
DA	PFC: Decreases "noise" via activation of D1Rs
PFC:	Regulation of behaviour, attention and affect using representational knowledge
Neurobiology of ADHD:	Cortical hypofunction Subcortical + subcortical regulation imbalance Catecholamine imbalance (coffee analogy)
ADHD Treatment:	Methylphenidate and atomoxetine Increases NA/DA, restores balance, improves function
ADHD Core symptoms	Inattention Impulsivity Hyperactivity
Buproprion	Smoking cessation
Methylphenidate	ADHD Cognitive enhancer NA/DA>5HT
Sibutramine	Eating disorders SSRI 5HT>>NA>>DA
Venaflaxine	Anxiety and eating disorders SSRI 5HT>NA>>DA
Atomexetine	ADHD treatment Cognitive enhancer NA>DA/5HT
DA	Drive
5HT	Impulse control and cognitive flexibility

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Cognitive enhancement

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	Created by Bhavi Mistry over 12 years ago