Cognitive enhancement

Question	Answer
Neurobiology of ADHD:	Cortical hypofunction Subcortical + subcortical regulation imbalance Catecholamine imbalance (coffee analogy)
PFC:	Regulation of behaviour, attention and affect using representational knowledge
DA	PFC: Decreases "noise" via activation of D1Rs
Clonidine	Alpha 2 antagonist Treatment of impulsivity
Desipramine	NA TCA Impulsivity treatment
Addiction	Correlation between low D2R numbers and addiction (+ liking the drug) Loss of control pathways - disruption of balance and ability to make rational decisions
Diseases of hypodopaminergic function	Cocaine addiction Alcoholism Obesity
alpha 2 receptors	Increase food intake Central regulation of food control
5HT 2C Rs	Decrease food intake Central control of food intake
Monoamines	5HT and NA Peripheral regulation of food intake
Beta 3 adrenoceptor	Increases thermogenesis Peripheral regulation of food intake
Hormonal control of feeding	NPY (leptin) Melanocrotin Galantin Insulin
Phentermine	Sympathomimetic Decreases feeding
Fenfluramine	SSRI Decreasing addiction
Rimonanabant	Selective CBIR blocker Control of addiction/feeding
Lorcaserin	Selective 5HT2C antagonist decrease of food intake
Orlistat	lipase inhibitor Peripheral treatment of obesity
NA	Locus coeruleus Vigilance
5HT	Impulse control and cognitive flexibility
DA	Drive
Atomexetine	ADHD treatment Cognitive enhancer NA>DA/5HT
Venaflaxine	Anxiety and eating disorders SSRI 5HT>NA>>DA
Sibutramine	Eating disorders SSRI 5HT>>NA>>DA
Methylphenidate	ADHD Cognitive enhancer NA/DA>5HT
Buproprion	Smoking cessation
ADHD Core symptoms	Inattention Impulsivity Hyperactivity
ADHD Treatment:	Methylphenidate and atomoxetine Increases NA/DA, restores balance, improves function

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Cognitive enhancement

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	Created by Bhavi Mistry about 11 years ago