Paraventricular Leukomalacia

Oligodendrocytes devoloping
1. OL progenitor, marker: NG2
  1. Pre-OL: O4 and NG2
    1. Immature OL; O4 and O1
      1. Mature OL: O1 and MBP
2. Vulnerability of OLs
  1. high ATP consumption
    1. hydrogen peroxide production
  2. Low Gluthione (antioxidant)
  3. CP-AMPARs?
  4. sphingolipids
    1. ceramide
      1. DR5 and CD95 clusters
OL's signalling
1. Organization
  1. Form Na+ clusters on axons
2. Signalling
  1. Receive excitatory input
Experimental models
1. Rodent OL are postnatal!
2. CNS hypoxiaischemia
3. Immune resonse: administrate bacterial lipopolysaccharides
Diagnosis
1. MRI, but not in unstable babies
2. Ultrasonography!
Prevention/treatments
1. Careful monitor PCO2 and other gases
Types and consequences
1. Focal vs. Diffuse
  1. Focal
    1. Microscopic
    2. Macroscopic
      Annotations:
      - About or less than 5% of babies with PVL
      1. Cystic or non-cystic

Resource summary

	Created by sanex_16 almost 12 years ago