which caused by damage to the tissues, either by
trauma or as a result of microbial multiplication.
2. CHemotaxis
Attraction of WBCs or other cells by
chemicals
3. Opsonization
Coating of a pathogen by substances to enhance phagocytosis
Opsonins are factors that include
antibodies and complement components
in plasma that coat pathogens and
facilitate phagocytosis
Opsonins are
also known as
the Fe portion of
antidbody and C3
4. Adherence
Firm contact between phagocyte and microorg
works well for whole bacteria or
viruses but less for proteins or
encapsulated bacteria
5. Engulfment
Into Cytoplasm and enclosed in a vacuole
6. Digestion
Enzyamtic contents in vacuole destroy the microorg.
The engulfment of cells or particulate
matter by neutrophils and
macrophages.
There are two major cells that use Phagocytosis to
remove pathogens in which are Polymorphonuclear cells and Mononuclear cells.
Polymorphonuclear Cells
1. Neutrophils
2. Basophils
3. Eosinophils
Are smaller cells, more abundant than macrophages
and travel quickly to a site of injury "MOMMIE Reaction
CELL" to gobble up any infecting bacteria that may have
entered/
Mononuclear Cells
1. Monocytes in the Plasma
2. Macrophages in tissues
These are large immune cells that patrol
the body looking for invaders or dead cells.
They also travel through bloodstream to
seekout cells to devour
Also are Efficient Phagocytes
DIfferentiated Phagocytes
Each Monocyte s specific to an organ, they remian in
that organ to patrol and attacak and invaders that enter
that specific organ.
Extra NOte: Various
molecules of the IS
collaborate with the INNATE
IS's cells
Is a type of Endocytosis
Endocystosis is the process in
which a cell absorbs a particle,
molecule, bacterium or other type
of matter by engulfing them.
Engulfs the larger, solid particles, most the time it is another cell.
Involves Ingestion and digestion of
Microorganisms
Insoluble particles
Damaged or Dead host cells
Cell Debris
Activated clotting Factors
The speed of phagocytosis can be increased markedly by bringing
tino action two attachment devices present on the surface of
phagocytic cells:
Fe Receptor: which binds the Fe portion of antibody molecules, chiefly IgG. The IgG will have attached
the organism via its Fab site.
Complement Receptor: The third
component of complement (C3) also
binds to organisms and then attaches
to the complement receptor.