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21222705
Platelet and coagulation disorders
Description
Mind Map on Platelet and coagulation disorders, created by Pooja Acharya on 09/03/2020.
Mind Map by
Pooja Acharya
, updated more than 1 year ago
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Created by
Pooja Acharya
over 4 years ago
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Resource summary
Platelet and coagulation disorders
Hemostasis
Sequence of events
Fibrinolysis
TPA
Plasmin
Fibrin
FDP
D-dimer
Marker of PE
Vasoconstriction
Neurohumoral
Endothelin
Primary plug
Platelet adhesion
VWF binds to GIb on platelets
VWF glues subendothelial collagen
Platelet shape change
Platelet activation
Release of platelet contents
Flip in the phospolipid membrane
ADP activates the GIIb receptor
Platelet aggregation
Binding GIIb betn platelets with fibrinogen
Secondary hemostatic plug
Coagulation cascade on platelet membrane
Instrinsic pathway
Surface activation FXII
PTT
50: 5O Correction
FVII, IX, XI, XII
50:50 correction
Circulating antibodies
SLE, APLA
Extrinsic pathway
PT
50:50 correction
FVII
50:50 no correction
Antibodies
Common pathway
X-->Xa
Proth--> Thrombin
Fibrinogen--> Fibrin
Clot stabilization
FXIII
Thrombophilia
Virchows triad
Hypercoagulability
Factor V L mutation
Va is resistant for inactivation by APC
AT-III Def
Thrombin uninhibited
PT gene mutation
Increased Prothrombin
HIT
Unfractioned heparin
Thrombocytopenia
Antibodies to PF-2
APLA
Antibodies to Glycoprotein I
False + VDRL
Rec PE
Repeated abortions
Libmann sack endocarditis
Stasis
Prolonged immobilization
Endothelial dysfunction
Smoking
Atherosclerosis
Thrombocytopenia
Decreased production
Marrow failure
Leukemia or infiltration
Decreased survival
Acute ITP
Child after viral
<20000 results in ICH
Chronic ITP
Antibodies to GPIb or GPIIb
Seen in females,
Diagnosis by exclusion
Quantitative disorder
Qualitative disorders
Bernard soulier
Adhesion defect absent GPib
RIPA reduced
Platelet count normal
Glanzmann
Platelet aggregation defect
Defective GPIIb/IIIa
Ristocetin -normal
VWD
VWF secreted from Endothelial cell
Adhesion defect
RIPA reduced
Desmopression increases release of VWF
MAHA
TTP
Neurological
Thrombocytopenia
Renal failure
Fever
Hemolytic anemia
Defect in ADMATS-13
HUS
Endothelial dysfunction due to toxin
After eating hamburger
Renal failure
No neurological manifestation
ECOLI O157:H7
DIC
Bleeding from iv canula
Extensive endothelial injury
TF release
etiology
Obstretic complications
Sepsis
severe burns
Lab diagnosis
Increased PT, PTT INR
Low platelets
Reduced fibrinogen
Coagulation factor defects
Hemophilia A
Raised PTT
50:50 Mix correction
FVIII DEF
X- Recessive
Hmeophilia B
FIX Deficiency
XR
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