Hemostasis

indysahota
Mind Map by , created about 6 years ago

Mind Map on Hemostasis, created by indysahota on 10/03/2013.

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indysahota
Created by indysahota about 6 years ago
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Hemostasis
1 Primary
1.1 Platelets
1.1.1 Abnormal function
1.1.2 Abnormal number
1.1.2.1 Sequestration
1.1.2.1.1 Splenomegaly
1.1.2.2 Increased destruction
1.1.2.2.1 Immune
1.1.2.2.1.1 ITP

Attachments:

1.1.2.2.1.1.1 Pathophysiology

Annotations:

  • Anti-platelet antibodies bind to platelets. Platelets get destroyed by spleen. 
1.1.2.2.1.1.1.1 Anti-platelet antibodies
1.1.2.2.1.1.2 Diagnosis

Annotations:

  • Diagnosis of exclusion
1.1.2.2.1.1.2.1 Diagnosis of exclusion
1.1.2.2.1.1.3 Presentation

Annotations:

  • - Asymptomatic - Minimal bruising to severe bleeding
1.1.2.2.1.1.3.1 Asymptomatic
1.1.2.2.1.1.3.2 Mild to severe bleeding
1.1.2.2.1.1.4 Investigations

Annotations:

  • - CBC and retics: thrombocytopenia - PT and PTT normal- Test for HIV and HCV (increased risk factors)- Blood smear: decreased platelets, giant platelets- Bone marrow biopsy: increased number of megakaryocytes
1.1.2.2.1.1.4.1 CBC and retics
1.1.2.2.1.1.4.1.1 Thrombocytopenia
1.1.2.2.1.1.4.2 PT and PTT
1.1.2.2.1.1.4.2.1 Normal
1.1.2.2.1.1.4.3 Bone marrow biopsy
1.1.2.2.1.1.4.3.1 Increased number of megakaryocytes
1.1.2.2.1.1.4.4 Blood smear
1.1.2.2.1.1.4.4.1 decreased and giant platelets
1.1.2.2.1.1.4.5 Test for HIV and HCV
1.1.2.2.1.1.5 Treatment
1.1.2.2.2 Non-immune
1.1.2.2.2.1 TTP
1.1.2.2.2.1.1 Pathophysiology
1.1.2.2.2.1.1.1 Can't breakdown vWF multimers
1.1.2.2.2.1.1.1.1 Congenital (ADAMST13)
1.1.2.2.2.1.1.1.2 Acquired
1.1.2.2.2.1.2 Presentation
1.1.2.2.2.1.2.1 Thrombocytopenia
1.1.2.2.2.1.2.1.1 Purpura
1.1.2.2.2.1.2.1.2 Hx of bleeding
1.1.2.2.2.1.2.1.3 Bruising
1.1.2.2.2.1.2.2 MAHA
1.1.2.2.2.1.2.2.1 (L) haptoglobin
1.1.2.2.2.1.2.2.2 (H) indirect bili
1.1.2.2.2.1.2.2.3 Retics
1.1.2.2.2.1.2.2.4 (H) LDH
1.1.2.2.2.1.2.3 Renal failure
1.1.2.2.2.1.2.4 Fever
1.1.2.2.2.1.2.5 Neurologic symptoms
1.1.2.2.2.1.2.5.1 Confusion
1.1.2.2.2.1.3 Investigations
1.1.2.2.2.1.3.1 CBC and blood smear
1.1.2.2.2.1.3.1.1 Schistocytes
1.1.2.2.2.1.3.1.2 (L) platelets
1.1.2.2.2.1.3.1.3 Indirect bili
1.1.2.2.2.1.3.1.4 (H) LDH
1.1.2.2.2.1.3.1.5 (L) haptoglobin
1.1.2.2.2.1.3.2 PT amd PTT
1.1.2.2.2.1.3.2.1 Normal
1.1.2.2.2.1.3.3 Coomb's test
1.1.2.2.2.1.3.3.1 Negative (non-immune)
1.1.2.2.2.1.3.4 Renal fxn
1.1.2.2.2.1.3.4.1 Creatinine
1.1.2.2.2.1.3.4.2 Urea
1.1.2.2.2.1.4 Diagnosis
1.1.2.2.2.1.4.1 Thrombocytopenia
1.1.2.2.2.1.4.2 MAHA
1.1.2.2.2.1.5 Treatment
1.1.2.2.2.1.5.1 Plasmapheresis
1.1.2.2.2.1.5.1.1 + steroids
1.1.2.2.2.1.5.2 Plasma transfusion
1.1.2.2.2.2 HIT
1.1.2.2.2.3 HUS
1.1.2.3 Decreased production
1.2 vWD
1.3 Vascular
2 Secondary

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