Hemostasis

Description

Mind Map on Hemostasis, created by indysahota on 10/03/2013.
indysahota
Mind Map by indysahota, updated more than 1 year ago
indysahota
Created by indysahota over 11 years ago
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Resource summary

Hemostasis
  1. Primary
    1. Platelets
      1. Abnormal function
        1. Abnormal number
          1. Sequestration
            1. Splenomegaly
            2. Increased destruction
              1. Immune
                1. ITP

                  Attachments:

                  1. Pathophysiology

                    Annotations:

                    • Anti-platelet antibodies bind to platelets. Platelets get destroyed by spleen. 
                    1. Anti-platelet antibodies
                    2. Diagnosis

                      Annotations:

                      • Diagnosis of exclusion
                      1. Diagnosis of exclusion
                      2. Presentation

                        Annotations:

                        • - Asymptomatic - Minimal bruising to severe bleeding
                        1. Asymptomatic
                          1. Mild to severe bleeding
                          2. Investigations

                            Annotations:

                            • - CBC and retics: thrombocytopenia - PT and PTT normal- Test for HIV and HCV (increased risk factors)- Blood smear: decreased platelets, giant platelets- Bone marrow biopsy: increased number of megakaryocytes
                            1. CBC and retics
                              1. Thrombocytopenia
                              2. PT and PTT
                                1. Normal
                                2. Bone marrow biopsy
                                  1. Increased number of megakaryocytes
                                  2. Blood smear
                                    1. decreased and giant platelets
                                    2. Test for HIV and HCV
                                    3. Treatment
                                  3. Non-immune
                                    1. TTP
                                      1. Pathophysiology
                                        1. Can't breakdown vWF multimers
                                          1. Congenital (ADAMST13)
                                            1. Acquired
                                          2. Presentation
                                            1. Thrombocytopenia
                                              1. Purpura
                                                1. Hx of bleeding
                                                  1. Bruising
                                                  2. MAHA
                                                    1. (L) haptoglobin
                                                      1. (H) indirect bili
                                                        1. Retics
                                                          1. (H) LDH
                                                          2. Renal failure
                                                            1. Fever
                                                              1. Neurologic symptoms
                                                                1. Confusion
                                                              2. Investigations
                                                                1. CBC and blood smear
                                                                  1. Schistocytes
                                                                    1. (L) platelets
                                                                      1. Indirect bili
                                                                        1. (H) LDH
                                                                          1. (L) haptoglobin
                                                                          2. PT amd PTT
                                                                            1. Normal
                                                                            2. Coomb's test
                                                                              1. Negative (non-immune)
                                                                              2. Renal fxn
                                                                                1. Creatinine
                                                                                  1. Urea
                                                                                2. Diagnosis
                                                                                  1. Thrombocytopenia
                                                                                    1. MAHA
                                                                                    2. Treatment
                                                                                      1. Plasmapheresis
                                                                                        1. + steroids
                                                                                        2. Plasma transfusion
                                                                                      2. HIT
                                                                                        1. HUS
                                                                                      3. Decreased production
                                                                                    3. vWD
                                                                                      1. Vascular
                                                                                      2. Secondary
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