250429
Mind Map on Hemostasis, created by indysahota on 10/03/2013.
45
0
0
|
Created by indysahota
about 6 years ago
|
|
Hemostasis
1 Primary
1.1 Platelets
1.1.1 Abnormal function
1.1.2 Abnormal number
1.1.2.1 Sequestration
1.1.2.1.1 Splenomegaly
1.1.2.2 Increased destruction
1.1.2.2.1 Immune
1.1.2.2.1.1 ITP
1.1.2.2.1.1.1 Pathophysiology
Annotations:
- Anti-platelet antibodies bind to platelets. Platelets get destroyed by spleen.
1.1.2.2.1.1.1.1 Anti-platelet antibodies
1.1.2.2.1.1.2 Diagnosis
Annotations:
- Diagnosis of exclusion
1.1.2.2.1.1.2.1 Diagnosis of exclusion
1.1.2.2.1.1.3 Presentation
Annotations:
- - Asymptomatic - Minimal bruising to severe bleeding
1.1.2.2.1.1.3.1 Asymptomatic
1.1.2.2.1.1.3.2 Mild to severe bleeding
1.1.2.2.1.1.4 Investigations
Annotations:
- - CBC and retics: thrombocytopenia - PT and PTT normal- Test for HIV and HCV (increased risk factors)- Blood smear: decreased platelets, giant platelets- Bone marrow biopsy: increased number of megakaryocytes
1.1.2.2.1.1.4.1 CBC and retics
1.1.2.2.1.1.4.1.1 Thrombocytopenia
1.1.2.2.1.1.4.2 PT and PTT
1.1.2.2.1.1.4.2.1 Normal
1.1.2.2.1.1.4.3 Bone marrow biopsy
1.1.2.2.1.1.4.3.1 Increased number of megakaryocytes
1.1.2.2.1.1.4.4 Blood smear
1.1.2.2.1.1.4.4.1 decreased and giant platelets
1.1.2.2.1.1.4.5 Test for HIV and HCV
1.1.2.2.1.1.5 Treatment
1.1.2.2.2 Non-immune
1.1.2.2.2.1 TTP
1.1.2.2.2.1.1 Pathophysiology
1.1.2.2.2.1.1.1 Can't breakdown vWF multimers
1.1.2.2.2.1.1.1.1 Congenital (ADAMST13)
1.1.2.2.2.1.1.1.2 Acquired
1.1.2.2.2.1.2 Presentation
1.1.2.2.2.1.2.1 Thrombocytopenia
1.1.2.2.2.1.2.1.1 Purpura
1.1.2.2.2.1.2.1.2 Hx of bleeding
1.1.2.2.2.1.2.1.3 Bruising
1.1.2.2.2.1.2.2 MAHA
1.1.2.2.2.1.2.2.1 (L) haptoglobin
1.1.2.2.2.1.2.2.2 (H) indirect bili
1.1.2.2.2.1.2.2.3 Retics
1.1.2.2.2.1.2.2.4 (H) LDH
1.1.2.2.2.1.2.3 Renal failure
1.1.2.2.2.1.2.4 Fever
1.1.2.2.2.1.2.5 Neurologic symptoms
1.1.2.2.2.1.2.5.1 Confusion
1.1.2.2.2.1.3 Investigations
1.1.2.2.2.1.3.1 CBC and blood smear
1.1.2.2.2.1.3.1.1 Schistocytes
1.1.2.2.2.1.3.1.2 (L) platelets
1.1.2.2.2.1.3.1.3 Indirect bili
1.1.2.2.2.1.3.1.4 (H) LDH
1.1.2.2.2.1.3.1.5 (L) haptoglobin
1.1.2.2.2.1.3.2 PT amd PTT
1.1.2.2.2.1.3.2.1 Normal
1.1.2.2.2.1.3.3 Coomb's test
1.1.2.2.2.1.3.3.1 Negative (non-immune)
1.1.2.2.2.1.3.4 Renal fxn
1.1.2.2.2.1.3.4.1 Creatinine
1.1.2.2.2.1.3.4.2 Urea
1.1.2.2.2.1.4 Diagnosis
1.1.2.2.2.1.4.1 Thrombocytopenia
1.1.2.2.2.1.4.2 MAHA
1.1.2.2.2.1.5 Treatment
1.1.2.2.2.1.5.1 Plasmapheresis
1.1.2.2.2.1.5.1.1 + steroids
1.1.2.2.2.1.5.2 Plasma transfusion
1.1.2.2.2.2 HIT
1.1.2.2.2.3 HUS
1.1.2.3 Decreased production
1.2 vWD
1.3 Vascular
2 Secondary