Endocrine Principles

Isa Sardar
Mind Map by Isa Sardar, updated more than 1 year ago
Isa Sardar
Created by Isa Sardar over 6 years ago
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Description

Brief description of the endocrine core principles as an introduction to the physiology of the endocrine system.

Resource summary

Endocrine Principles
  1. 3 types of hormones
    1. Amines; tyrosine-derived
      1. Catecholamines (water-soluble)
        1. Thyroid Hormones T3/4 (hydrophobic)
        2. Peptides (basically all other hormones)
          1. Hypothalamic hormones (except dopAMINE)
            1. Pituitary hormones
              1. GIT hormones
              2. Steroids (cholestrol derivative)
                1. Sex Hormones (androgens)
                  1. Adrenal Cortex Hormones; Aldosterone + Cortisol + androgens
                    1. Renal 1,25-Dihydroxycholecalciferol
                  2. 3 stimuli for hormone secretion
                    1. Tropic Hormones
                      1. Hormones that stimulate hormone secretion. Eg: hypothalamic or pituitary hormones.
                      2. Plasma levels of minerals, glucose, hormones.
                        1. Since most hormones regulate the levels of salt, sugar, and functional hormones in the body, thus their levels are homeostasically intertwined with (and regulated by) them.
                        2. Neurotransmitters
                          1. Involvement of the CNS indicates that hormone secretion is also regulated by thoughts, emotions, or autonomic signals etc.
                        3. Clearance
                          1. Rate of removal of hormone from the blood; metabolic clearance rate = Rate of disappearance from blood / Plasma concentration of hormone
                            1. 3 types
                              1. Renal Excretion
                                1. Hepatic modification or excretion into bile
                                  1. Interstitial/Intercellular metabolism
                                2. Permisiveness
                                  1. Some hormones cause up-regulation of receptors and intracellular signaling proteins for another hormone, creating a greater than normal sensitivity to that other hormone's stimulatory function.
                                    1. Ex: Thyroid hormones up-regulate B-Adrenergic receptors for catcholamines, enhancing their effects in the body.
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