NEPHRON

NEPHRON

1.RENAL CORPUSCLE
1. made up of : GLOMELURUS [ PART OF BLOOD CAPILLARY] and BOWMAN’S CAPSULE [PART OF NEPHRON ] LOCATED IN CORTEX
2. SMALL MOLECULES [ ABSORBED ] - WATER (H2O ) - SMALL MOLECULES
3. LARGE MOLECULES [ REMAIN IN BLOOD ] - LARGE PROTEINS - BLOOD CELLS
4. Filtrate : WASTE PRODUCT + VALUABLE NUTRIENTS
2. PROXIMAL CUMULUTED TUBULE
1. made up of cuboidal cell [ numerous microvilli ]
  1. microvilli - increase surface are for reabsorbtion
2. reabsorbs ( ELECTROLYTES , WATER , GLUCOSE , AMINO ACIDS , POLYPEPTIDES)
3. ↑IN WASTES ↓ IN NUTRIENTS
3. LOOP OF HENLE
1. DESCENDING ( THIN SEGMENT ) MADE OF SQUAMOS EPITHELIAL TISSUE
  1. ↑ PERMEABLE IN WATER
  2. IMPERMEABLE TO SOLUTES
  3. FLUID MORE CONCENTRATED AS IT FLOWS DEEPER IN THE MEDULLA
2. ASCENDING – MADE OF CUBOIDAL EPITHELIAL CELLS
  1. THIN ↑ LIMB -Na+ & Cl- PUMPED OUT OF TUBULE
  2. THICK ↑ LIMB - FLUID LESS CONCENTRATED AS IT MOVES UP THE TUBULE
4. DISTAL CUMULUTED TUBULE
1. MADE OF : EARLY → CUBOIDAL EPITHELIAL CELLS LATE → PRINCIPAL & INTERCALATED CELLS
  1. • INTERCALATED CELLS RESPONSIBLE FOR SECRETION OF H+ • PRINCIPLE CELLS (UNDER HORMONAL CONTROL
    1. ALDOSTERONE - Na+ LEVEL IN THE BLOOD ↓ ADH - DEHYDRATION
2. SECRETE - IONS ,ACIDS,DRUGS,TOXINS
3. REABSORBED - H2O , Na+ , Cl-
5. COLLECTING DUCT
1. MEDULLA COLLECTING DUCT - PRINCIPAL & INTERCALATED CELLS
  1. REABSORBS & SECRETES WATER AND UREA UNDER HORMONAL CONTROL
2. CORTICAL COLLECTING DUCT – PRINCIPAL CELLS
  1. ALDESTERONE (√) REABSORBS Na+ SECRETES K+ & H+ ALDESTERONE (X) REABSORBS K+
  2. ADH (√) REABSORBS MORE H2O
http://www.docenten.science.ru.nl/pklaren/42_A01/42_A01.swf

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