Phospholipase C Pathway

PLC is a membrane-assoiciated enzyme
1. Activated by the G-protein that it is located close to.
are 2 second messengers associated with this pathway:
1. 1,2- diacylglycerol (DAG)
2. inositol 1,4,5-triphosphate (IP3)
  1. Both of these can freely diffuse in the cytosol
  2. IP3 opens Ca2+ channels in the endoplasmic reticulum membrane.
    1. causes a rise in intracellular Ca2+
      1. recruits Protein Kinase C (PKC) to the plasma membrane
        DAG activates PKC
        The activated membrane-assoiciated kinase can phosphorylate cellular enzymes and receptors (altering their activity).
    2. ER stores get depleted
      1. So, proteins assoiciated with the IP3-gated Ca2+ channels open store-operated Ca2+ channels in the plasma membrane
        This allows influx of extracellular Ca2+
        Balanced :D
3. both arise from the cleavage of phosphatidyl inositol 4,5-biphosphate (PIP2)
on activation, PLC cleaves a membrane phospholipid called PIP2, yielding 2 second messengers:

Resource summary

	Created by Sophie Barrett about 10 years ago