Enzyme-Linked Receptors

Characteristics
1. Often exist as inactive monomers
2. Ligand binding induces activation by di/trimerisation
3. the monomers transphosphorylate each other
4. adaptor proteins recognise change in structure
Transforming Growth Factor Beta (A Ligand)
1. brings the monomers together (that exist seperatly)
  1. Heterodimerisation occurs (the monomers are not idetical)
    1. Phosphorylation occurs on the serine-threonine residues
      1. This ultimately activates the TGF receptor
Nerve Growth Factor (NGF) (A Ligand)
1. NGF presence causes homodimerisation of receptors with intrinsic cytosolic tyrosine kinase activity
  1. Phosphorylation occurs on the tyrosine residues
  2. note here, that the monomers are identical
Cytokines
1. Heterodimerisation of receptors...
  1. whose cytosolic domains are associated with seperate non-tyrosine kinases
Receptor Tyrosine Kinase Signalling
1. Trk Receptors = Tropomyosin-related Kinases
  1. The receptor for NGF is TrkA
  2. The receptor for BDNF (brain-derived neurotrophic factor) is TrkB
  3. The receptor for NT3 (Neurotrophin-3) is Trk C
  4. The receptor for NT4/5 is Trk B

Resource summary

	Created by Sophie Barrett about 10 years ago