Enzyme-Linked Receptors

Sophie Barrett
Mind Map by Sophie Barrett, updated more than 1 year ago
Sophie Barrett
Created by Sophie Barrett about 6 years ago
32
1

Description

Undergraduate Cellular Pathology (Signal Transduction Pathways) Mind Map on Enzyme-Linked Receptors, created by Sophie Barrett on 02/14/2014.

Resource summary

Enzyme-Linked Receptors
1 Characteristics
1.1 Often exist as inactive monomers
1.2 Ligand binding induces activation by di/trimerisation
1.3 the monomers transphosphorylate each other
1.4 adaptor proteins recognise change in structure
2 Transforming Growth Factor Beta (A Ligand)
2.1 brings the monomers together (that exist seperatly)
2.1.1 Heterodimerisation occurs (the monomers are not idetical)
2.1.1.1 Phosphorylation occurs on the serine-threonine residues
2.1.1.1.1 This ultimately activates the TGF receptor
3 Nerve Growth Factor (NGF) (A Ligand)
3.1 NGF presence causes homodimerisation of receptors with intrinsic cytosolic tyrosine kinase activity
3.1.1 Phosphorylation occurs on the tyrosine residues
3.1.2 note here, that the monomers are identical
4 Cytokines
4.1 Heterodimerisation of receptors...
4.1.1 whose cytosolic domains are associated with seperate non-tyrosine kinases
5 Receptor Tyrosine Kinase Signalling
5.1 Trk Receptors = Tropomyosin-related Kinases
5.1.1 The receptor for NGF is TrkA
5.1.2 The receptor for BDNF (brain-derived neurotrophic factor) is TrkB
5.1.3 The receptor for NT3 (Neurotrophin-3) is Trk C
5.1.4 The receptor for NT4/5 is Trk B
Show full summary Hide full summary

Similar

Cell Signalling 1
Sophie Barrett
Signal Transduction Pathways with Glutamate Receptors
Sophie Barrett
Skeletal Muscle
Sophie Barrett
Heart Myocytes
Sophie Barrett
Glutamate
Sophie Barrett
Phospholipase C Pathway
Sophie Barrett
Adenylyl Cyclase Pathway
Sophie Barrett
Allosteric Regulation by Protein Phosphorylation
Sophie Barrett
Post Translational Modifications
Sophie Barrett
Apoptosis vs Necrosis
Hannah Rowley