Regulation of Na+ & Cl- Balance

Regulation of Na+ & Cl- Balance

1. Regulation of filtered load of Na+ (via GFR)

   • Na+ reabsorption at DCT and CCD via the action of aldosterone (major control of Na+ excretion).
   • nearly all Na+ in filtrate is reabsorbed: 65% in PCT, 25% in asc LoH.

2. Regulation of Na+ reabsorption

3. Macula densa cells

   • lower concentrations in Na+
     • activate Mesangial cells
   • higher concentrations in Na+
     • adenosine release

4. Mesangial cells

   • secrete renin

5. Renin system in Hemorrhage

6. renin system

7. Short-term regulation of blood pressure

8. regulation of blood pressure

9. Pressure natriuresis and diuresis

10. Summary of regulation of blood pressure via the kidney

11. BP regulation in diarhhea

Images and files in the map