Muhammed spleen is palpable


Mind Map on Muhammed spleen is palpable, created by Dana Alobadily on 05/08/2017.
Dana Alobadily
Mind Map by Dana Alobadily, updated more than 1 year ago
Dana Alobadily
Created by Dana Alobadily about 7 years ago

Resource summary

Muhammed spleen is palpable
  1. Differences between
    1. leukocytosis: increase in the number of WBCs .' non neoplastic"
      1. Neutrophilic leukocytosis: (count >7000cells/ mm3)
        1. Bacterial infections- Corticosteroids (inhinit margination) -Myocardial infarction
        2. Lymphocytosis: (Absolute count >4000cells/ mm3
          1. Viral infections (infectious mononucleosis) -Drugs (phynetoin)
          2. Eosiniophilia
            1. Type I hypersensitivity reaction (bronchial asthma- reaction to penicillin)- Helminthic infection
            2. Monocytosis
              1. Chronic infections : TB
            3. leukomoid reaction:This is a reactive and excessive leukocytosis."mimic leukemia"
              1. WBC counts up to 15 - 100,000/mm3
                1. Shift to the left (immature WBCs)
                  1. Signs of activation Doehle bodies, toxic granulations (Differs the condition from CML)
                    1. toxic granulation
                      1. Doehle bodies
                        1. NAP scores high (Differs the condition from CML)
                          1. MPO negative (Myeloperoxidase) to differ from CML
                      2. Hematological neoplasms
                        1. Hematological History Taking
                          1. Hematology Physical Examination
                            1. Chronic Myeloid Leukemia
                              1. phases
                                1. confirming tests
                                  1. FISH
                                    1. PCR
                                      1. Karyotyping
                                        1. Bone Marrow Biopsy in accelerated phase
                                        2. presence of Philadelphia chromosome 22 due to translocation
                                          1. Fusion of 2 genes: BCR (or chromosome 22) and ABL1 (on chromosome 9), resulting in BCR-ABL1 fusion gene
                                          2. Management
                                            1. tyrosine kinase inhibitor
                                              1. imatinib
                                                1. inhibit TK enzyme
                                              2. Hematopoietic stem cell transplantation
                                              3. clinical presentation
                                                1. Asymptomatic
                                                  1. abdominal fullness due to splenomegaly
                                                    1. weight loss - fatigue
                                                  2. Investigations
                                                    1. CBC
                                                      1. Blood film
                                                        1. Blood film at 1000X magnification shows a promyelocyte, an eosinophil, and 3 basophils.
                                                          1. Blood film at 400X magnification demonstrates leukocytosis with the presence of precursor cells of the myeloid lineage. In addition, basophilia, eosinophilia, and thrombocytosis can be seen.
                                                        Show full summary Hide full summary


                                                        AS Unit 2 Physics Flashcard Deck
                                                        Callum McClintock
                                                        Great Expectations
                                                        Jodee Phillips
                                                        GCSE CHEMISTRY UNIT 2 STRUCTURE AND BONDING
                                                        Types and Components of Computer Systems
                                                        Jess Peason
                                                        OCR Physics P4 Revision
                                                        Dan Allibone
                                                        Tests for Positive Ions: Flame Test Colours
                                                        Chapter 5: Short-term and Working Memory
                                                        Renal System A&P
                                                        Kirsty Jayne Buckley
                                                        1_PSBD New Edition
                                                        Ps Test
                                                        Část 4.
                                                        Gábi Krsková