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903226
Molar pregnancy/ hydatidiform mole
Description
Mind Map on Molar pregnancy/ hydatidiform mole, created by Zulhilmi Zainal on 05/20/2014.
Mind Map by
Zulhilmi Zainal
, updated more than 1 year ago
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Created by
Zulhilmi Zainal
over 10 years ago
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Resource summary
Molar pregnancy/ hydatidiform mole
an egg that is missing its nucleus is fertilized and that may or may not contain fetal tissue
complete moles
single (90%) or two (10%) sperm combining with an egg which has lost its DNA (the sperm then reduplicates forming a "complete" 46 chromosome set
higher risk of developing into choriocarcinoma
all the chorionic villi are vesicular, and no sign of embryonic or fetal development is present
partial mole
an egg is fertilized by two sperm or by one sperm which reduplicates itself yielding the genotypes of 69,XXY (triploid) or 92,XXXY (tetraploid)
fetus is always malformed and is never viable
spontaneous abortion if untreated
Clinical presentation
painless vaginal bleeding in the fourth to fifth month of pregnancy
uterus may be larger than expected, or the ovaries may be enlarged
hyperemesis
very high levels of human chorionic gonadotropin (hCG)
"cluster of grapes" or "honeycombed uterus" or "snow-storm"
increased trophoblast proliferation and enlarging of the chorionic villi
sonogram & histopathological examination
Treatment
surgical curettage
avoid the risks of choriocarcinoma
avoid pregnancy for at least 6 to 12 months
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