Antimicrobial Drugs

Mind Map by , created over 5 years ago

Mind Map on Antimicrobial Drugs, created by lippoldm on 05/28/2014.

Created by lippoldm over 5 years ago
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Antimicrobial Drugs
1 Works on Cell Wall
1.1 Peptidoglycan cross-linking inhibition= no wall synthesis
1.1.1 Penicillinase Resistant Naficillin Staph. Aureus; except MRSA Interstitial Nephritis Oxacillin Dicloxacillin Aztreonam Gram NEG RODS ONLY!! Vancomycin Gram POSITIVE ONLY! Multi-drug resistant organisms MRSA, Enterococci, & C.diff RED MAN SYNDROME (diffuse flushing) Nephrotoxicity, Ototoxiicity, Thrombophlebitis
1.1.2 NOT resistant to B-lactamase Penicillin (B-lactam) 1.Gram + organisms w/ no B-lactamase, 2.Neisseria M. 3.Treponema Pallidum Hemolytic Anemia Ampicillin/AmOxicillin EXTENDED SPECTRUM: 1.H.influenzae 2.E.coli 3.Listeria M. 4.Proteus Mirabilis 5.Salmonella 6.Shigella Pseudomembranous Colitis +Clavulanic Acid/ Tazobactam/ Sulbactam (B-lactamase inhibitor) Ticarcillin/ Piperacillin Pseudomonas Cephalosporins First Generation Cefazolin/cephalexin Prior to surgery for Staph a. 1. ProteusM. 2.E.coli 3.Klebsiella Vit K deficiency 2nd generation Ceftriaxone Meningitis and Gonorrhea Ceftiazidime Pseudomonas
2 Protein Synthesis Inhibitors
2.1 30S inhibitors
2.1.1 Aminoglycosides Gentomycin Neomycin Streptomycin Nephrotoxicity Ototoxicity NM blockage
2.1.2 Tetracyclines Tetracycline Deoxycycline Borrelia Burgdorferi M.pneumonia Rickettsia Chlamydia Teeth discoloration Bone growth inhibition Photosensitivity
2.2 50S inihibitors
2.2.1 Chloramphenicol MENINGITIS (H.influenza, N. meningitis, Strep. pneum) Anemia Pancytopenia
2.2.2 Erythromycin Azithromycin Atypical pneumonias (Mycoplasma & LEGIONELLA= Eryth #1) Chlamydia Strep infections in pencillin allergy Motility problems Arrythmia Cholestatic hepatits Rash Eosinophilia
2.2.3 Clindamycin Pseudomembranous colitis; ASPIRATION PNEUMONIA (alcoholics) = works against oral anaerobes & G+ aerobes (S.pneum) ; and oral infections w/ mouth anaerobes Treats anaerobes ABOVE the diaphragm vs Metronidazole that works BELOW
3 Others:
3.1 Isoniazid (INH)
3.1.1 Myco. TB (& prophylaxis) Neurotoxicity (due to similar structure to B6)
3.2 Rifampin
3.2.1 Mycob. TB ORANGE Urine
3.3.1 (Trimethoprim- Sulfamethoxazole) HIV prophylaxis Hx of recurrent UTI's
3.4 TB Treatment
3.4.1 Prophylaxis Isoniazid
3.4.2 Active infection treatment drugs Isoniazid Rifampin Ethambutol Pyrazinamide Only one that works best in LOW pH and INTRACELLULARLY I/E work on the cell wall. Rif- inhibits DNA- dependent RNA polymerase Pyra-kills intracellularly
3.5 '-floxacin' (Fluroquinolones)
3.5.1 Inhibit DNA gyrase & topoisomerase IV G- rods of urinary and GI tracts; Neisseria DONT take with ANTACIDS!! GI upset; Superinfections; TENDONITIS; Tendon rupture; Myalgias
3.6 Metranidazole
3.6.1 Forms free radicals in the bacteria Treats ANAEROBIC infections BELOW the diaphragm; Giardia; Entamoeba; Trichomonas; Gardnerella vaginalis; and H.pylori (+clarithromycin & PPI) Disulfiram-like rxn w/ alcohol; METALLIC TASTE

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