IMMUNITY - created from Mind Map

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INNATE IMMUNITY

Physical Barrier

Stages of infection

skin

mucous membrane

natural flora

Natural secretion

Adherence of pathogen

Penetration of epithilium

Local infection of the tissue

ADAPTED IMMUNITY

Stages of infection

Lymphocytes : Cells with receptors that are highly specific

lymphatic spread

Adaptive immunity

Cell mediated Tcells

Humoral Bcells

originate in bone marrow but mature in thymus and found tissue and blood

Naieve Tcell

CD4+

CD8

cells origniate and develop in the bone marrow

Naieve Bcell

Plasma Cells

Memory Cells

Antibodies

Structure

Function

diversity

Types

Neutralisation

Oponisation

Lysis

Antibody dependent cellular toxicity

IGM

IGG

IGA

IGD

IGE

A body's ability to resist a particular diesase whether natural or as a result of a previous infection

Antigen : molecules recognnised by immune system inducing an immune response. Can be prtoeins , carbohydrates , nucleic scid , lipids or lipopolysacharides

-slow

- first line of defence

Activated when the antibody on the B cell recognises an antigen through contact with epitome engulfs it and presents it throgugh an MHC CLASS 2 - helper T cell then comes along rtecognises it and assist B cells to differenciate

Composed to two heavy chains , two domains and two chains.

Has a variable domain and constant domain

Light chain and heavy chain '

Fc regioin binds to other cell

Fab regions binds to antigen

The diversity comes from the splicing that occurs with the genes.

Heavy chain is encoded by VDJC and

Light chain is encoded by VJC

recombination creates unique antibodies per cell

Rearrangment VH3DH7JH5 = all matieral b/w v3 to d7 is deleted along with matieral b/w d7 to h5 all the matieral upstream and downstream kept

Variation in heavy chain constant regioin detemines isotype

Intially make IgM in naieve cells but then upon maturation make isotypes throgyuh class swithching as the variable regions remainsthe same the specifiicity does not chain just the affinity

-expressed in naeive B cells

-pentamer

-not a high affinity antibody

-linked by J chains

-very effiecient activating compliment

Major class is serum

major class in secodnary response

binds receptor exposed by monocytes

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IMMUNITY

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