Quiz
1.5
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Perguntas do quiz (32)
1The three parts of each nucleotide are
- Acytosine, ribose, phosphate
- Bamino group, phosphate, pentose sugar
- Cphosphate, ribose, nitrogenous base
- Dnitrogenous base, phosphate, pentose sugar
2For the DNA sequence, 5'-ATCGATCGATCGATCG-3', which of the following represents the sequence and polarity of the complementary strand?
- A5'-ATCTATCGATCGATCG-3'
- B5'-CGATCGATCGATCGAT-3'
- C3'-ATCGATCGATCGATCG-5'
- D3'CGATCGATCGATCGAT-5'
3Okazaki fragments are
- Asynthesized by telomerase
- Bfound on the lagging strand
- Cfound on the leading strand
- Dassembled as continuous replication
4Which of the following statements about DNA replication in E. coli is correct?
- AIt proceeds with one replication fork per replicating molecule
- BIn involves discontinuous synthesis in the leading strand
- CIt uses RNA as a template
- DIt is bidirectional
5This enzyme is responsible for copying DNA
- ARNase H
- BPrimase
- CDNA polymerase
- DLigase
6All of the following statements about telomerase are correct, EXCEPT
- ARNA component acts as a template for the synthesis of a segment DNA
- Badds telomeres to the 5' ends of the DNA strand
- CProvides a mechanism for replicating the ends of linear chromosomes
7Given the diagram below, what type of base-pair mutation has occurred?
CGTCACA --> CGTUACA- ATransition
- BTransversion
- CInsertion
- DFrameshift
8Which of the following statements about DNA replication in prokaryotes is true
- AHas multiple points of origin
- BIt involves continuous DNA synthesis in both strands
- CAll prokaryotic DNA polymerases are not capable of proofreading
- DDoes not require topoisomerase
9Which of the following statements about ribonucleotide reductase is true
- AIt contains two kinds of allosteric regulatory sites, one for control of overall activity and another for control of substrate specificity
- BIt converts 2'-deoxyribonucleoside dipohsphate into ribonucleoside diphosphates
- Cit catalyzes the addition of pyrophosphate
10The conversion of dUMP to dTMP by thymidylate synthase requires which of the following
- Athiodoxin
- Bribonucleotide synthetase
- CN5, N10- methylenetetrahydrofolate
- Dglutathion
11Lesch Nyhan syndrome is due to the inability to catalyze which of the following reactions?
- AAdenine to AMP
- BAdenosine to AMP
- CGuanine to GMP
- DThymine to TMP
12The reason the amount of A-T and G-C (Chargaff's rule) is because
- Apurines base-pair with pyrimidines
- Bphosphates alternate with pentose sugars in the DNA backbone
- CX-ray diffraction indicated a double-helical pattern in DNA
- DDNA has polatiry
13Allopurinol can be used to treat gout because of its ability to inhibit which of the following reactions
- AAMP to XMP
- BXanthine to uric acid
- CIMP to XMP
- DXMP to GMP
14Which of the following statements about nucleotide synthesis is true
- APRPP is utilized in purine de novo synthesis but not in purimidine de novo synthesis
- BPRPP participates in purine salvage pathways
- CDe novo synthesis of purines does not require ATP
- DIn purine synthesis, the nitrogenous base is made first, followed by addition of ribose sugar
15Which of the following amino acids contribute atoms utilized in purine biosynthesis
- AAsp, Gly, Gln
- BAsp, Gly, Gln, Phe
- CAsp, Gly, Phe
16One of the end products of purimidine catabolism is
- Auric acid
- Bbeta-alanine
- Cfumarate
- Dhypoxanthine
175-flurouracil, an anti-metabolite, is used as an anti-tumor agent by inhibiting the production of which following compounds
- AdUMP
- BdTMP
- Cxanthine
- DTMP
18Which of the following statements about pyrimidine synthesis is true
- AAspartate and glutamine are required
- Bcarbamoyl phosphate synthetase II is activated by UDP
- CDoes not require PRPP
- Dis inhibited by ATP
19In a DNA molecule, the
- Abases are covalently bounded to one another
- Bsugars are composed of 8 carbon rings
- Cbases are hydrogen bonded to one another
- Dphosphates are hydrogen bonded to one another
20Double stranded DNA consists of two antiparallel strands, meaning that one strand is oriented in the 5' to 3' direction, while the other is oriented in the 3' to 5' direction
- Atrue
- Bfalse
21Which of the following DNA molecules is the most stable
- ATCAGCTTA
- BGACGTATG
- CCTTTAAAG
- DCGCACGTG
22A eukaryotic chromosome is made of
- ADNA
- BHistones and nucleic acid
- Cloops of naked DNA
- DDNA and RNA
23Three types of DNA involved in protein synthesis, comprising the structural and functional core, serving as a template for translation, and transporting amino acid
- AmRNA, tRNA, rRNA
- BrRNA, tRNA, mRNA
- CtRNA, mRNA, rRNA
- DrRNA, mRNA, tRNA
24In which phase of the cell cycle does DNA synthesis occur
- AG1
- BS
- CG2
- DM
25DNA replication results in two identical daughter molecules each consisting of one old strand and one newly-synthesized strand
- AVerdadeiro
- BFalso
26Identify the DNA template and coding strand for the following mRNA
5'- AUG CGU AAG UCA UAA-3'- A3'- TAC GCA TTC AGT ATT-5'
5'-ATG CGT AAG TCA TAA-3' - B3’-UAC GCA UUC AGU AUU-5’,
5’-AUG CGU AAG UCA UAA-3’ - C3’-ATG CGT AAG TCA TAA -5’,
5’-TAC GCA TTC AGT ATT -3’ - D 5’-TAC GCA TTC AGT ATT-3’,
3’-ATG CGT AAG TCA TAA-5’
- A3'- TAC GCA TTC AGT ATT-5'
27Which of the following processes is involved in the termination of transcription in prokaryotic cells?
- ABinding of the helicase Rho to the mRNA molecule
- BBinding of the s factor to the promoter region of the DNA template
- CAddition of a poly(A) tail to the 3’ end of the mRNA molecule
- DBinding of the mRNA molecule to a release factor (RF-1 or RF-2)
28Which of the following events occurs during the initiation of translation in prokaryotic cells?
- ABinding of the initiator tRNA with a formylated methionine to the start codon in
the mRNA molecule with the help of initiation factor IF-2 - B Binding of the Shine-Delgarno sequence to the A-site of the small ribosomal
subunit - CDelivery of an aminoacyl-tRNA to the A-site of the ribosome with the help of
initiation factor IF-2 - DBinding of the initiation factor IF-1 to the P-site of the small ribosomal subunit
- ABinding of the initiator tRNA with a formylated methionine to the start codon in
29After the aminoacylation reaction is completed we say that the tRNA is charged because:
- AAn amino acid is attached to the acceptor stem of the tRNA molecule
- BThe 3’ end of the tRNA molecule has received a poly(A) tail
- CThe OH group at the 3’ end of the acceptor stem has been capped
- D The tRNA will contain a branch point
30Translation termination requires that the ______.
- AGTP-bound elongation factor EF-Tu recognizes one of the Stop codons
- BGTP-bound release factors 1 OR 2 (RF-1 or RF-2) recognizes one of the Stop
codons - CGTP-bound initiation factor IF-2 recognizes one of the Stop codons
- D Formation of a hairpin in the mRNA structure
31What is the role of the s factor during transcription in prokaryotes?
- AThe s factor recognizes the promoter in the template strand
- BThe s factor binds to the helicase Rho in order to terminate transcription
- CThe s factor is responsible for proofreading during synthesis of the mRNA molecule
- DThe s factor promotes the transition from initiation to elongation by binding to the
C-terminal domain (CTD) in the RNA polymerase
32Which of the following applies ONLY to transcription in prokaryotic but not eukaryotic cells?
- A.Transcription of functionally related genes is organized in operons
- BInitiation of RNA synthesis requires the identification of the promoter by general
transcription factors - CRNA polymerase II is responsible for the synthesis of the mRNA molecule
- DTranscription is regulated by the presence of distal regulatory elements in the
template strand
Informações
- Descrição
- Quiz sobre 1.5, criado por Esther Yook em 21-09-2015.
- Autor
- Esther Yook
- Idioma
- English
- Visualizações
- 14
- Histórico
- Criado em 21 set 2015 · atualizado em 19 fev 2016
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