Flashcards
Path bone pathology (2)
Flashcards do conjunto (34)
- 1focal osteoporotic bone marrow defect hematopoeitic bone marrow defectasymptomatic UL RL with trabeculations visible running thru
post mandible
no expansion
adult females
hist: hematopoietic or fatty bone marrow - 2idiopathic osteosclerosisfocal area of incr radiodensity
sharply demarcated with no RL rim
unknown cause (no pathosis)
asymptomatic, non-expansile
VITAL mand M and PM area (not restricted to jaws)
young people
histo: sclerotic vital bone (biopsy not indicated tho) - 3condensing osteitis chronic focal sclerosing osteomyelitisfocal opacity assoc with pathosis
well-defined, no RL border
NON VITAL mand M and PM
not separated from apex of tooth
young adults - 4retained root tipwell demarcated RO
- 5socket sclerosisdense bone formed in area of extraction
form of osteosclerosis - 6sub-pontic osseous hyperplasiareactive condition which causes hyperplastic production of bone beneath pontic
tx: sg - 7gardner syndromeAD
presents with osteomas and jaw densities, supernumerary teeth, intestinal polyps with malig transformation (adenocarcinoma) - 8pseudocyst of maxillary sinus antral pseudocystRO dome shaped lesion in maxillary sinus
NO BIOPSY - 9submandibular salivary gland cyst stafne cyst static bone cavity latent bone cystnot a true cyst (no epi lining)
lingual development defect--lobe of SM gland fills
well-defined RL between mand canal and inf border
no tx - 10traumatic bone cyst idiopathic bone cavity hemmorhagic bone cyst simple bone cystNOT A TRUE CYST (no epi lining)
due to trauma/hemorrhage
mostly male teens/yg adults
mandible
asymptomatic RL with scalloped border
rare expansion
surround vital teeth (no root resorb)
biopsy initiates healing - 11aneurysmal bone cystNOT A TRUE CYST
RL, often ML
rapidly growing, may blow out cortex
painful
mandible (or any bone)
young individuals <20 yrs
ballooning dilation of bone, "blood soaked sponge" appearance
hemosiderin staining
histo: cyst like cavity filled with blood and multinucleated giant cells - 12osteogenesis imperfecta brittle bone ds lobstein dsAD or AR defective synthesis of type 1 collagen
extreme bone fragility, deformity, short, joint laxity
skull: too little bone, cortical thinning, attenuate trabeculae
blue sclera
dentigerous imperfecta: bluish discoloration, obliteration of pulp
may be misdx as child abuse
tx: bisphosphonates (risk of MRONJ) - 13osteopetrosis marble bone disease albers schoneberg dsrare genetic ds in which bone density is incr
AR infantile is most severe, AD adult is least severe
reduced osteoclast bone resorption (reduced acid profuction) resulting in diffuse, symmetric sclerosis
progressive obliteration of bone marrow-->neutropenia, anemia, extramed hematopoeisis
easy fracture
narrowing of skull foramina-->blind, deaf, paralysis, venous drain
delayed tooth eruption
osteomyelitis
tx: hematopoetic cell transplant - 14osteomyelitis vs osteonecrosisosteomyelitis: vital bone with inflammatory cells in marrow spaces
osteonecrosis: nonvital bone with bact debris in marrow spaces - 15Paget's ds of bone osteitis deformansexcessive remodeling of bone caused by osteoclast dysfunction (NF-kb mutation)
possible paramyxovirus origin
progression from initial lytic stage (RL)-->mixed lytic-sclerotic --> late sclerotic (RO)
older individuals
monostotic or polyostotic
impinges on foramina-->pain, headache, visual dist
change in hat size, denture fit
enlarge skull, maxilla enlargement (lion's face)
"cotton wool" bone and hypercementosis
complications: osteomyelitis, osteosarcoma, bowing of legs, path fracture, CF
tx: bisphospohonates (MRONJ), calcitonin
hist: reversal lines, mosaic jigsaw pattern - 16benign fibro-osseous lesions fibrous dysplasia osseous dysplasia ossifying fibromanormal bone replaced with mineralized fibrous CT
origins: devl, reactive, neoplasms
RL or RO unilateral enlargement
ground glass appearance
monostotic (Craniofacial) > polyostotic (mcune albright, jaffe lichenstein)
histo: chinese characters - 17McCune Albright syndromesevere form of fibrous dysplasia
Bone lesions: bowing legs, shepards hook, ground glass with expansion
skin: cafe au lait
endocrinopathy - 18Jaffe-Lichenstein Syndromemild form of fibrous dysplasia
Bone lesions: bowing legs, shepards hook, ground glass with expansion
skin: cafe au lait - 19cemento osseous dysplasiareactive benign fibro-osseous lesion (most common)
arises from PDL elements
spectrum of ds from localized to generalized
cementum and bone depositions - 20PA Cemento-osseous dysplasiabenign fibrosseous lesion in PA of ant mandible
black females 30-50 yo
aymptomatic, assoc with vital teeth
RL --> mixed --> RO
multiple >> solitary lesions - 21florid cemento-osseous dysplasiabenign fibrosseous lesion with multifocal involvement, often bilateral and symm
black females 30-50 yo
aymptomatic, assoc with vital teeth
RL --> mixed --> RO with thin RL outline - 22focal cemento-osseous dysplasiabenign fibrosseous lesion in post mandible and extraction sites
middle aged adults
aymptomatic, assoc with vital teeth
thin peripheral RL rim "bullseye" - 23cemento-ossifying fibromabenign neoplasm, fibro-osseous lesion
middle aged females
M and PM of mandible
RL and mixed
expansion may displace teeth
biopsy comes out in one complete piece - 24cherubismAD condition in kids
bilateral jaw RL with giant cell histo
over time lesions may resolve
histo: multinucleated giant cells - 25central giant cell granulomaUL or ML solitary RL in anterior jaw, crossing midline
10-30 yo females
cortical expansion with perf uncommon, resorption of tooth roots
tx: curretage + corticosteroids/calcitonin/IF A2
histo: multinucleated giant cells - 26browns tumor of hyperparathyroidismsame radio and histo as CGCG
blood levels indicate hyper parathyroidism: incr serum ca, decr serum phos, incr PTH - 27giant cell tumor of long bonetrue neoplasm, ML RL
found in epiphyseas of long bones of adults
metastasis to lung - 28langerhans cell histiocytosisneoplastic prolif of histiocytes
"floating teeth" and punched out RL
chronic focal: solitary lesion in bone
chronic disseminated (hands schuller christian): multiple bones, organs, lymph nodes, skin
acute disseminated: affects kids, organs, bone marrow, skin
histo: histocytes with birbeck granulaes - 29metaplastic carcinomamost common malig neoplasm in bone
- 30osteosarcomamost common malig neoplasm arising FROM bone
bone/osteoid, chrondroid, and collagen
most common in long bones around knees
pain, swelling
hx of extraction
lytic or sclerotic; sunburst appearance, ill-defined margins, widened PDL
tx: sg and chemo
complicates pagets - 31post irridation bone sarcomarelated to radiation dose
causes osteosarcoma, fibrosarcoma, chrondosarcoma
hist and prog identical to de novo tumors - 32chrondosarcomamalig neoplasm in which cartilage is formed by malig stroma
maxilla
widened PDL with opaque bone appearance; sunburst - 33ewing sarcomamalignancy of young people
pain, swelling
mimics infec with fever, leukocytes, elev ESR
pelvis and lower extremeties most common
onion skin periosteal rxn
translocation T(11:22)
chemo + sg/radio - 34multiple myelomamost common neoplasm arising WITHIN bone
disseminated neoplasm of terminally differentiated B-cells
multiple lytic lesion, hypercalcemia, bone pain
punched out RL, lose teeth, pain, amyloidosis, path frac
lab: elev serum ca, prot, Ig; elev ESR, rouleaux, M spike
may lead to renal failure, infec, anemia
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- SP D2 FlashCards sobre Path bone pathology (2), criado por Katie Hayes em 03-04-2020.
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- Katie Hayes
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