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| Questão | Responda |
| Diabetes Mellitus | Disturbance of glucose homeostasis |
| Action of insulin on: - Liver - Muscle - Fat | - inhibits gluconeogenesis & increase glycogen production - increase protein synthesis - increase fat storage |
| Insulin deficiency or resistance results in... | - Gluconeogenesis - Protein catabolism - Lipolysis |
| 3 factors causing HYPERGLYCAEMIA in DM | 1. Decreased tissue utilisation of glucose, amino acids and fatty acids 2. Increased hepatic gluconeogenesis 3. Accumulation of dietary glucose in circulation |
| Type I DM | 1. Commonly seen in DOGS 2. Insulin- dependent 3. Immune-mediated destruction of pancreatic beta cells that results in progressive and complete loss of insulin secretion 4. Absolute requirement for exogenous insulin |
| Type II DM | 1. Commonly seen in CATS 2. Non-insulin dependent 3. Impaired insulin secretion by dysfunctional beta cells and peripheral insulin resistance (i.e. impairs post-prandial glucose uptake) 4. Loss of beta cell function is usually progressive and may result in complete loss of insulin secretion |
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